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This lecture covers the use of macro-materials in tissue engineering, focusing on key components such as cells, scaffolds, and signaling molecules. It discusses bio-implants, non-bioresorbable materials like breast implants, and bioresorbable materials. The classification of scaffold materials, including natural and synthetic polymers, is explained. The lecture also delves into the properties of ideal scaffolds, bioresorbable polymers like PLA and PLGA, and the absorption time of bioresorbable materials. It explores the compositions of extracellular matrix components, collagen structure, and the construction of scaffolds to resemble ECM. The use of hydrogels and injectable hydrogels in tissue engineering, as well as decellularized scaffolds and fabrication of porosity in scaffolds, are also discussed.