Molecular machines involved in mycobacterial protein quality control pathways

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Protein Induced Degradation: Druggability Strategy

Explores protein-induced degradation to enhance target druggability and the use of PROTACS in drug development.

Frontiers in Chemical Biology

Explores the druggable proteome, PROTACS strategy, ubiquitin attachment, and drug development paradigms.

Protein Structure & Modifications

Explores protein structure analysis, folding, modifications, and their impact on diseases and protein activity regulation.

Membrane Protein Quality Control at ER

Explores membrane protein quality control mechanisms at the ER, focusing on ERAD recognition, retrotranslocation, ubiquitination, and degradation of misfolded proteins.

PROTACs: Catalytic Protein Knockdown Strategy

Explores PROTACs, a catalytic protein knockdown strategy with potential in tumor treatment and drug development.

Analyzing Post-Translational Modifications: Techniques and Challenges

Covers the analysis of post-translational modifications using mass spectrometry, focusing on techniques, challenges, and the significance of phosphoproteomics.

Protein Phosphorylation: Mechanisms & Regulation

Explores protein phosphorylation, detailing common modifications like acetylation and ubiquitination, kinase specificity, and activation mechanisms.