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This lecture covers various engineering challenges related to distributed systems, energy harvesting, and system building. Topics include automatic control, communication limits, sensors, actuators, large-scale distributed systems, interaction with natural sciences, new models, and methods. Challenges such as sensor-actuator coupling, energy balancing, predictability, reliability, and modeling are discussed. The importance of maintaining core disciplinary knowledge, providing new models, and methods, as well as the risks and benefits of system engineering are highlighted.