Protein Interactions & Membrane Binding

This lecture covers the domains involved in protein interactions and membrane binding, focusing on lipid-binding domains and scaffolds enabling protein interactions. It discusses the importance of protein-protein interactions in cellular organization, the role of scaffolds in bringing proteins together, and the manipulation of protein location and activation. The instructor explains the concept of effective molarity and how scaffolds enhance local concentrations, leading to accelerated chemical kinetics. The lecture also delves into genome-wide approaches to studying protein interactions, the specificity of protein domains, and the significance of poly-pharmacology in drug development.