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This lecture delves into the era of personalized medicine, exploring gene therapy advancements and the revolutionary CRISPR technology. It covers the tragic case of 'Bubble boy' David, gene therapy research articles, challenges in gene delivery, and the groundbreaking CRISPR-Cas9 system. The lecture also discusses the biotech applications of CRISPR, including gene editing strategies, ex vivo and in vivo therapy approaches, and correction of pathogenic gene mutations in human embryos. Ethical implications of synthetic genomics and synthetic biology are also addressed, emphasizing the need for effective oversight mechanisms and informed discourse involving various disciplines.