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This lecture covers the mechanisms and processes involved in DNA replication, including the initiation at a specific origin, bidirectional replication, the role of the replisome machinery, and the proofreading mechanisms. It also discusses the replication of circular DNA molecules, the involvement of various proteins such as helicase and DNA polymerase, and the key steps in the replication process. The lecture concludes with a focus on the proofreading mechanisms and the significance of accurate DNA replication.