Total Synthesis: Strategies and Impact

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Related lectures (21)

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Multicomponent Reactions: Principles and Applications

Covers Multicomponent Reactions, their principles, applications, and total synthesis examples.

Retrosynthesis: Complex Fragments Synthesis Strategy

Explores the retrosynthesis strategy for complex fragments synthesis, using Leucascandrolide A as a case study.

Pharmacokinetic & Pharmacodynamic Studies

Discusses the importance of assessing PK/PD relationships in drug development and the use of multiple PD biomarkers.

Peptide Therapeutics

Explores the development and advantages of peptide therapeutics, including conversion into peptidomimetics and solid phase peptide synthesis.

Pharmacokinetics: Drug Absorption and Distribution

Explores drug absorption, distribution, and clinical implications, focusing on salicylate poisoning and drug trapping in lysosomes.

Mannich Reaction: Applications and Mechanism

Explores the Mannich reaction, its applications in natural product synthesis, and related reactions.

Heterocyclic Chemistry: Synthesis and Applications

Covers the structure, guidelines, goals, content, and applications of heterocyclic chemistry.

Protein Induced Degradation: Druggability Strategy

Explores protein-induced degradation to enhance target druggability and the use of PROTACS in drug development.

Kinase Inhibitors: Types and Mechanisms

Explores kinase inhibitors, enzyme inhibition methods, transition state analog drugs, and the significance of covalent drugs in pharmaceutical research.

Pharmacological Targets and Interventions

Explores targets for drug action and the design of specific inhibitors.