Genetic Toggle Switch: Bistability and Oscillations

This lecture covers the genetic toggle switch, a bistable system composed of two genes mutually repressing each other. The instructor explains the conditions for bistability and the role of promoters and repressors. The lecture delves into the basic ingredients of the toggle switch, such as lacI, tetR, and lambda repressors, and discusses the impact of external controls like IPTG and aTc. The presentation also explores the concept of limit cycle oscillators and the cycle of glycolysis in yeast as an example of metabolic oscillations. The lecture concludes with the potential applications of the toggle switch in gene therapy and biotechnology.