Publications by Rodrigo de Campos Perin

Of mice and men: Dendritic architecture differentiates human from mouse neuronal networks

Henry Markram, Kathryn Hess Bellwald, Rodrigo de Campos Perin, Lida Kanari, Ying Shi, Julie Meystre, Alexis Arnaudon, Maurizio Ferdinando Pezzoli, Natali Barros Zulaica

The organizational principles that distinguish the human brain from other species have been a long-standing enigma in neuroscience. Focusing on the uniquely evolved human cortical layers 2 and 3, we computationally reconstruct the cortical architecture for ...

2025

Fear learning induces synaptic potentiation between engram neurons in the rat lateral amygdala

Henry Markram, Rodrigo de Campos Perin

The lateral amygdala (LA) encodes fear memories by potentiating sensory inputs associated with threats and, in the process, recruits 10-30% of its neurons per fear memory engram. However, how the local network within the LA processes this information and w ...

Nature Portfolio2024

Cell density quantification of high resolution Nissl images of the juvenile rat brain

Henry Markram, Olivier Burri, Rodrigo de Campos Perin, Ying Shi, Julie Meystre, Daniel Keller

Copyright © 2024 Meystre, Jacquemier, Burri, Zsolnai, Frank, Vieira, Shi, Perin, Keller and Markram.Nissl histology underpins our understanding of brain anatomy and architecture. Despite its importance, no high-resolution datasets are currently available i ...

2024

Thalamic control of sensory processing and spindles in a biophysical somatosensory thalamoreticular circuit model of wakefulness and sleep

Henry Markram, Sean Lewis Hill, Michael Reimann, Rodrigo de Campos Perin, James Gonzalo King, Ying Shi, Rajnish Ranjan, Mustafa Anil Tuncel, Samuel Claude Kerrien, Polina Litvak

2023

A calcium-based plasticity model for predicting long-term potentiation and depression in the neocortex

Henry Markram, Eilif Benjamin Muller, Rodrigo de Campos Perin, James Gonzalo King, Vincent Delattre, Mustafa Anil Tuncel, Werner Alfons Hilda Van Geit, Marwan Muhammad Ahmed Abdellah, Pramod Shivaji Kumbhar, Giuseppe Chindemi

Pyramidal cells (PCs) form the backbone of the layered structure of the neocortex, and plasticity of their synapses is thought to underlie learning in the brain. However, such long-term synaptic changes have been experimentally characterized between only a ...

Nature Portfolio2022

Estimating the Readily-Releasable Vesicle Pool Size at Synaptic Connections in the Neocortex

Henry Markram, Eilif Benjamin Muller, Srikanth Ramaswamy, Rodrigo de Campos Perin, Giuseppe Chindemi, Natali Barros Zulaica

Previous studies based on the 'Quantal Model' for synaptic transmission suggest that neurotransmitter release is mediated by a single release site at individual synaptic contacts in the neocortex. However, recent studies seem to contradict this hypothesis ...

2019

Objective Morphological Classification of Neocortical Pyramidal Cells

Henry Markram, Kathryn Hess Bellwald, Srikanth Ramaswamy, Rodrigo de Campos Perin, Lida Kanari, Ying Shi, Julie Meystre, Marwan Muhammad Ahmed Abdellah, Yun Wang

A consensus on the number of morphologically different types of pyramidal cells (PCs) in the neocortex has not yet been reached, despite over a century of anatomical studies, due to the lack of agreement on the subjective classifications of neuron types, w ...

Oxford University Press (OUP)2019

On the Structure of Cortical Microcircuits Inferred from Small Sample Sizes

Rodrigo de Campos Perin

The structure in cortical microcircuits deviates from what would be expected in a purely random network, which has been seen as evidence of clustering. To address this issue, we sought to reproduce the nonrandom features of cortical circuits by considering ...

Soc Neuroscience2017

Cliques of Neurons Bound into Cavities Provide a Missing Link between Structure and Function

Henry Markram, Kathryn Hess Bellwald, Rodrigo de Campos Perin, Michael Reimann, Giuseppe Chindemi, Martina Scolamiero, Max Christian Nolte, Ran Levi, Katharine Felicity Turner, Pawel Tadeusz Dlotko

The lack of a formal link between neural network structure and its emergent function has hampered our understanding of how the brain processes information. We have now come closer to describing such a link by taking the direction of synaptic transmission i ...

Frontiers Media Sa2017

Cell-type- and activity-dependent extracellular correlates of intracellular spiking

Henry Markram, Rodrigo de Campos Perin, Constantinos Anastassiou

Despite decades of extracellular action potential (EAP) recordings monitoring brain activity, the biophysical origin and inherent variability of these signals remains enigmatic. We performed whole-cell patch recordings of excitatory and inhibitory neurons ...

2015