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Benjamin Rappaz

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Automated multi-parameter measurement of cardiomyocytes dynamics with digital holographic microscopy

Gerardo Turcatti, Benjamin Rappaz, Pierre Marquet

Compounds tested during drug development may have adverse effects on the heart; therefore all new chemical entities have to undergo extensive preclinical assessment for cardiac liability. Conventional intensity-based imaging techniques are not robust enoug ...

Optical Society of America2015

Phase Retrieval by Using Transport-of-Intensity Equation and Differential Interference Contrast Microscopy

Michaël Unser, Daniel Sage, Benjamin Rappaz, Emrah Bostan, Emmanuel Augustin Julien Froustey

We present a variational reconstruction algorithm for the phase-retrieval problem by using the differential interference contrast microscopy. Principally, we rely on the transport-of-intensity equation that specifies the sought phase as the solution of a p ...

IEEE2014

Loss of Protein Tyr-phosphorylation During in vitro Storage of Human Erythrocytes: Impact on RBC Morphology

Gerardo Turcatti, Niels Erik Lion, Benjamin Rappaz, Pierre Marquet, Michel Prudent

Wiley-Blackwell2014

Digital holographic microscopy: a quantitative label-free microscopy technique for phenotypic screening

Gerardo Turcatti, Benjamin Rappaz, Etienne Shaffer

Digital Holographic Microscopy (DHM) is a label-free imaging technique allowing visualization of transparent cells with classical imaging cell culture plates. The quantitative DHM phase contrast image provided is related both to the intracellular refractiv ...

2014

Label-Free Cytotoxicity Screening Assay by Digital Holographic Microscopy

Pierre Magistretti, Christian Depeursinge, Gerardo Turcatti, Benjamin Rappaz, Marc Chambon, Jonas Kühn, Etienne Shaffer, Jérôme Parent, Julien Mena

We introduce a label-free technology based on digital holographic microscopy (DHM) with applicability for screening by imaging, and we demonstrate its capability for cytotoxicity assessment using mammalian living cells. For this first high content screenin ...

Mary Ann Liebert2013

Simultaneous Optical Recording in Multiple Cells by Digital Holographic Microscopy of Chloride Current Associated to Activation of the Ligand-Gated Chloride Channel GABA(A) Receptor

Christian Depeursinge, Benjamin Rappaz, Pierre Marquet, Pascal Jourdain, Daniel Boss, Corinne Moratal

Chloride channels represent a group of targets for major clinical indications. However, molecular screening for chloride channel modulators has proven to be difficult and time-consuming as approaches essentially rely on the use of fluorescent dyes or invas ...

Public Library of Science2012

Spatially-Resolved Eigenmode Decomposition of Red Blood Cells Membrane Fluctuations Questions the Role of ATP in Flickering

Pierre Magistretti, Dimitri Nestor Alice Van De Ville, Christian Depeursinge, Benjamin Rappaz, Pierre Marquet, Daniel Boss, Annick Hoffmann

Red blood cells (RBCs) present unique reversible shape deformability, essential for both function and survival, resulting notably in cell membrane fluctuations (CMF). These CMF have been subject of many studies in order to obtain a better understanding of ...

Public Library Science2012

Determination of Transmembrane Water Fluxes in Neurons Elicited by Glutamate Ionotropic Receptors and by the Co-transporters KCC2 and NKCC1: A Digital Holographic Microscopy Study

Pierre Magistretti, Christian Depeursinge, Benjamin Rappaz, Pierre Marquet, Nicolas Pavillon, Pascal Jourdain, Daniel Boss, Corinne Moratal

Digital holographic microscopy (DHM) is a noninvasive optical imaging technique that provides quantitative phase images of living cells. In a recent study, we showed that the quantitative monitoring of the phase signal by DHM was a simple label-free method ...

Society for Neuroscience2011

Red blood cell structure and dynamics explored with digital holographic microscopy

Pierre Magistretti, Christian Depeursinge, Benjamin Rappaz, Pierre Marquet, Pascal Jourdain, Daniel Boss

2009

Spatial analysis of erythrocyte membrane fluctuations by digital holographic microscopy

Pierre Magistretti, Christian Depeursinge, Benjamin Rappaz, Pierre Marquet, Daniel Boss, Annick Hoffmann

Red blood cell (RBC) membrane fluctuations provide important insights into cell states. We present a spatial analysis of red blood cell membrane fluctuations by using digital holographic Microscopy (DHM). This interferometric and dye-free technique, posses ...

Elsevier2009

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