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Patrick Fraering

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Alzheimer's disease mutations in APP but not γ-secretase modulators affect epsilon-cleavage-dependent AICD production

Highly efficient production of the Alzheimer's γ-Secretase integral membrane protease complex by a multi-gene stable integration approach

Use of waste products for detecting amyloidogenic proteinaceous material in living mammals

Alzheimer's Disease-Linked Mutations in Presenilin-1 Result in a Drastic Loss of Activity in Purified gamma-Secretase Complexes

Selective neutralization of APP-C99 with monoclonal antibodies reduces the production of Alzheimer's Aβ peptides

Generation of monoclonal antibody fragments binding the native γ-secretase complex for use in structural studies

Therapeutic antibodies targeting app-c99

Discovery of a novel pharmacological and structural class of gamma secretase modulators derived from the extract of Actaea racemosa

Mercury is a direct and potent γ-secretase inhibitor affecting Notch processing and development in Drosophila