Kristina Schoonjans

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A SIRT7-Dependent Acetylation Switch of GABPβ1 Controls Mitochondrial Function

Johan Auwerx, Kristina Schoonjans, Alessia Perino, Dongryeol Ryu, Hongbo Zhang, Matthias Alexander Sokrates Stein, Giuseppe Lo Sasso

Mitochondrial activity is controlled by proteins encoded by both nuclear and mitochondrial DNA. Here, we identify Sirt7 as a crucial regulator of mitochondrial homeostasis. Sirt7 deficiency in mice induces multisystemic mitochondrial dysfunction, which is ...

Cell Press2014

TGR5 reduces macrophage migration through mTOR-induced C/EBP beta differential translation

Kristina Schoonjans, Alessia Perino, Matthias Alexander Sokrates Stein, Mitsunori Nomura, Thijs Pols

The bile acid-responsive G protein-coupled receptor TGR5 is involved in several metabolic processes, and recent studies suggest that TGR5 activation may promote pathways that are protective against diet-induced diabetes. Here, we investigated the role of m ...

American Society for Clinical Investigation2014

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The vitamin D endocrine system has many extraskeletal targets, including adipose tissue. 1,25-Dihydroxyvitamin D-3, the active form of vitamin D, not only increases adipogenesis and the expression of typical adipocyte genes but also decreases the expressio ...

Nature Publishing Group2014

Bile Acids Alter Male Fertility Through G-Protein-Coupled Bile Acid Receptor 1 Signaling Pathways in Mice

Kristina Schoonjans

Bile acids (BAs) are signaling molecules that are involved in many physiological functions, such as glucose and energy metabolism. These effects are mediated through activation of the nuclear and membrane receptors, farnesoid X receptor (FXR-alpha) and TGR ...

Wiley-Blackwell2014

Another Shp on the Horizon for Bile Acids

Kristina Schoonjans, Alessia Perino

Bile acid metabolism is tightly controlled due to the toxic effects of bile acid overload. In this issue, research from the Feng lab reports Shp2 as a novel integrator of hepatic bile acid and FGF15/FGF19 signaling, adding another layer of complexity to th ...

Cell Press2014

SIRT2 Deficiency Modulates Macrophage Polarization and Susceptibility to Experimental Colitis

Johan Auwerx, Kristina Schoonjans, Alessia Perino, Alessandra Piersigilli, Adrienne Joëlle Laurence Mottis, Keir Joe Menzies, Hiroyasu Yamamoto, Giuseppe Lo Sasso

Background: SIRT2 belongs to a highly conserved family of NAD(+)-dependent deacylases, consisting of seven members (SIRT1-SIRT7), which vary in subcellular localizations and have substrates ranging from histones to transcription factors and enzymes. Recent ...

Public Library of Science2014

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Oxford University Press2014

Bmj Publishing Group2014

Loss of Sirt1 function improves intestinal anti-bacterial defense and protects from colitis-induced colorectal cancer

Johan Auwerx, Kristina Schoonjans, Laurent Mouchiroud, Dongryeol Ryu, Alessandra Piersigilli, Elena Katsyuba, Giuseppe Lo Sasso

Dysfunction of Paneth and goblet cells in the intestine contributes to inflammatory bowel disease (IBD) and colitis-associated colorectal cancer (CAC). Here, we report a role for the NAD+-dependent histone deacetylase SIRT1 in the control of anti-bacterial ...

Public Library of Science2014

In the ovary, the follicular granulosa cells express the nuclear receptor Nr5a2 (nuclear receptor subfamily 5 group A member 2), also known as liver receptor homolog-1, and after ovulation, Nr5a2 expression persists in the corpus luteum. Previous studies d ...

Endocrine Soc2014

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