Kristina Schoonjans

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Muscle or liver-specific Sirt3 deficiency induces hyperacetylation of mitochondrial proteins without affecting global metabolic homeostasis

Johan Auwerx, Kristina Schoonjans, Carlos Canto Alvarez, Pénélope Andreux, Norman Lionel Moullan, Eija Riitta Pirinen, Hiroyasu Yamamoto, Taoufiq Harach, Pablo Jose Fernandez Marcos, Ellen Helena Jeninga

Sirt3 is a mitochondrial sirtuin, predominantly expressed in highly metabolic tissues. Germline ablation of Sirt3 has major metabolic consequences, including increased susceptibility to metabolic damage and oxidative stress after high fat feeding. In order ...

2012

LRH-1-dependent glucose sensing determines intermediary metabolism in liver

Johan Auwerx, Kristina Schoonjans, Norman Lionel Moullan, Chikage Mataki, Hiroyasu Yamamoto, Taoufiq Harach, Maaike Hélène Oosterveer

Liver receptor homolog 1 (LRH-1), an established regulator of cholesterol and bile acid homeostasis, has recently emerged as a potential drug target for liver disease. Although LRH-1 activation may protect the liver against diet-induced steatosis and insul ...

American Society for Clinical Investigation2012

TGR5 potentiates GLP-1 secretion in response to anionic exchange resins

Johan Auwerx, Kristina Schoonjans, Mitsunori Nomura, Thijs Pols, Taoufiq Harach, Adriano Maida

Anionic exchange resins are bona fide cholesterol-lowering agents with glycemia lowering actions in diabetic patients. Potentiation of intestinal GLP-1 secretion has been proposed to contribute to the glycemia lowering effect of these non-systemic drugs. H ...

2012

The NAD+ Precursor Nicotinamide Riboside Enhances Oxidative Metabolism and Protects against High-Fat Diet-Induced Obesity

Johan Auwerx, Kristina Schoonjans, Carlos Canto Alvarez, Pénélope Andreux, Karl Gademann, Richardus Houtkooper, Eija Riitta Pirinen, Hiroyasu Yamamoto, Maaike Hélène Oosterveer, Pablo Jose Fernandez Marcos

As NAD(+) is a rate-limiting cosubstrate for the sirtuin enzymes, its modulation is emerging as a valuable tool to regulate sirtuin function and, consequently, oxidative metabolism. In line with this premise, decreased activity of PARP-1 or CD38-both NAD(+ ...

Elsevier2012

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Metabolic homeostasis is achieved by complex molecular and cellular networks that differ significantly among individuals and are difficult to model with genetically engineered lines of mice optimized to study single gene function. Here, we systematically a ...

Cell Press2012

Bile Acid Binding Resin Improves Metabolic Control through the Induction of Energy Expenditure

Johan Auwerx, Kristina Schoonjans, Chikage Mataki

Besides well-established roles of bile acids (BA) in dietary lipid absorption and cholesterol homeostasis, it has recently become clear that BA is also a biological signaling molecule. We have shown that strategies aimed at activating TGR5 by increasing th ...

Public Library of Science2012

TGR5 in macrophages is protective against atherosclerosis and insulin resistance

Johan Auwerx, Kristina Schoonjans, Mitsunori Nomura, Thijs Pols

Wiley-Blackwell2012

The bile acid membrane receptor TGR5 as an emerging target in metabolism and inflammation

Johan Auwerx, Kristina Schoonjans, Lilia Noriega Lopez, Mitsunori Nomura, Thijs Pols

Bile acids (BAs) are amphipathic molecules that facilitate the uptake of lipids, and their levels fluctuate in the intestine as well as in the blood circulation depending on food intake. Besides their role in dietary lipid absorption, bile acids function a ...

Elsevier2011

The bile acid membrane receptor TGR5: a valuable metabolic target

Johan Auwerx, Kristina Schoonjans, Lilia Noriega Lopez, Mitsunori Nomura, Thijs Pols

Bile acids (BAs) are amphipathic molecules that facilitate the uptake of lipids, and their levels fluctuate in the intestines as well as in the circulation depending on food intake. Besides their role in dietary lipid absorption, BAs function as signaling ...

2011

Lowering bile acid pool size with a synthetic farnesoid X receptor (FXR) agonist induces obesity and diabetes through reduced energy expenditure

Johan Auwerx, Kristina Schoonjans, Chikage Mataki

We evaluated the metabolic impact of farnesoid X receptor (FXR) activation by administering a synthetic FXR agonist (GW4064) to mice in which obesity was induced by a high fat diet. Administration of GW4064 accentuated body weight gain and glucose intolera ...

2011

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