Publications by Wojciech Janusz Bobela

Modulation of AMPK's activity via genetic tools and food-derived compounds as a novel approach to Parkinson's disease treatment

Aging is considered as a major risk factor for Parkinsonâ s disease (PD) and can be defined as a gradual decline in the ability of biological systems to efficiently renew structural and functional components, which may lead to perturbations in energetic h ...

EPFL2016

Alpha-Synuclein as a Mediator in the Interplay between Aging and Parkinson's Disease

Patrick Aebischer, Bernard Schneider, Wojciech Janusz Bobela

Accumulation and misfolding of the alpha-synuclein protein are core mechanisms in the pathogenesis of Parkinson's disease. While the normal function of alpha-synuclein is mainly related to the control of vesicular neurotransmission, its pathogenic effects ...

Mdpi Ag2015

PGC-1 alpha activity in nigral dopamine neurons determines vulnerability to alpha-synuclein

Bernard Schneider, Graham Knott, Lu Zheng, Wojciech Janusz Bobela

Introduction: Mitochondrial dysfunction and oxidative stress are critical factors in the pathogenesis of age-dependent neurodegenerative diseases. PGC-1 alpha, a master regulator of mitochondrial biogenesis and cellular antioxidant defense, has emerged as ...

2015

Nigrostriatal overabundance of alpha-synuclein leads to decreased vesicle density and deficits in dopamine release that correlate with reduced motor activity

Patrick Aebischer, Graham Knott, Marco Cantoni, Ralf Schneggenburger, Özgür Genç, Jean-Charles Bensadoun, Wojciech Janusz Bobela, Safa Mohanna

alpha-Synuclein (alpha-syn) is a presynaptic protein present at most nerve terminals, but its function remains largely unknown. The familial forms of Parkinson's disease associated with multiplications of the alpha-syn gene locus indicate that overabundanc ...

Springer-Verlag2012