Publications by Giuseppe Lo Sasso

Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents

Johan Auwerx, Maria del Carmen Sandi Perez, Patrick Aebischer, Dongryeol Ryu, Laurent Mouchiroud, Elena Katsyuba, Pénélope Andreux, Norman Lionel Moullan, Evan Graehl Williams, Pooja Jha

The biological effects of urolithins remain poorly characterized, despite wide-spread human exposure via the dietary consumption of their metabolic precursors, the ellagitannins, which are found in the pomegranate fruit, as well as in nuts and berries. We ...

2016

A SIRT7-Dependent Acetylation Switch of GABPβ1 Controls Mitochondrial Function

Johan Auwerx, Kristina Schoonjans, Alessia Perino, Dongryeol Ryu, Hongbo Zhang, Matthias Alexander Sokrates Stein, Giuseppe Lo Sasso

Mitochondrial activity is controlled by proteins encoded by both nuclear and mitochondrial DNA. Here, we identify Sirt7 as a crucial regulator of mitochondrial homeostasis. Sirt7 deficiency in mice induces multisystemic mitochondrial dysfunction, which is ...

Cell Press2014

SIRT2 Deficiency Modulates Macrophage Polarization and Susceptibility to Experimental Colitis

Johan Auwerx, Kristina Schoonjans, Alessia Perino, Adrienne Joëlle Laurence Mottis, Alessandra Piersigilli, Keir Joe Menzies, Hiroyasu Yamamoto, Giuseppe Lo Sasso

Background: SIRT2 belongs to a highly conserved family of NAD(+)-dependent deacylases, consisting of seven members (SIRT1-SIRT7), which vary in subcellular localizations and have substrates ranging from histones to transcription factors and enzymes. Recent ...

Public Library of Science2014

Loss of Sirt1 function improves intestinal anti-bacterial defense and protects from colitis-induced colorectal cancer

Johan Auwerx, Kristina Schoonjans, Laurent Mouchiroud, Dongryeol Ryu, Elena Katsyuba, Alessandra Piersigilli, Giuseppe Lo Sasso

Dysfunction of Paneth and goblet cells in the intestine contributes to inflammatory bowel disease (IBD) and colitis-associated colorectal cancer (CAC). Here, we report a role for the NAD+-dependent histone deacetylase SIRT1 in the control of anti-bacterial ...

Public Library of Science2014

Mitochondrial sirtuins and metabolic homeostasis

Johan Auwerx, Eija Riitta Pirinen, Giuseppe Lo Sasso

The maintenance of metabolic homeostasis requires the well-orchestrated network of several pathways of glucose, lipid and amino acid metabolism. Mitochondria integrate these pathways and serve not only as the prime site of cellular energy harvesting but al ...

Elsevier Sci Ltd2012

TGR5 Activation Inhibits Atherosclerosis by Reducing Macrophage Inflammation and Lipid Loading

Johan Auwerx, Kristina Schoonjans, Mitsunori Nomura, Thijs Pols, Taoufiq Harach, Maaike Hélène Oosterveer, Giuseppe Lo Sasso

The G protein-coupled receptor TGR5 has been identified as an important component of the bile acid signaling network, and its activation has been linked to enhanced energy expenditure and improved glycemic control. Here, we demonstrate that activation of T ...

Cell Press2011