Person
Tao Xu
This person is no longer with EPFL
Related publications (15)
An adaptive phase field approach to 3D internal crack growth in rocks
Alexandra Roma Larisa Kushnir, Tao Xu, Michael Heap
Modeling the 3D internal crack under compression entails complex fracture mechanics (mode I-II-III fracture), resulting in substantial computational costs and challenges in characterizing fracture morphology characterization for Phase Field Method (PFM) si ...
2024Towards artificial methanogenesis: biosynthesis of the [Fe]-hydrogenase cofactor and characterization of the semisynthetic hydrogenase
The greenhouse gas and energy carrier methane is produced on Earth mainly by methanogenic archaea. In the hydrogenotrophic methanogenic pathway the reduction of one CO2 to one methane molecule requires four molecules of H-2 containing eight electrons. Four ...
Royal Soc Chemistry2017Nickel pincer model of the active site of lactate racemase involves ligand participation in hydride transfer
Rosario Scopelliti, Xile Hu, Matthew Wodrich, Tao Xu
Pincer complexes are widely applied in homogeneous catalysis. However, only very recently has the first pincer complex been discovered in the active site of a metalloenzyme, namely, lactate racemase. Here, we report a synthetic model of the active site of ...
Natl Acad Sciences2017A Water-Bridged H-Bonding Network Contributes to the Catalysis of the SAM-Dependent C-Methyltransferase HcgC
[Fe]-hydrogenase hosts an iron-guanylylpyridinol (FeGP) cofactor. The FeGP cofactor contains a pyridinol ring substituted with GMP, two methyl groups, and an acylmethyl group. HcgC, an enzyme involved in FeGP biosynthesis, catalyzes methyl transfer from S- ...
2017A Functional Model of [Fe]-Hydrogenase
Rosario Scopelliti, Xile Hu, Matthew Wodrich, Tao Xu, Simona Mazza
[Fe]-Hydrogenase catalyzes the hydrogenation of a biological substrate via the heterolytic splitting of molecular hydrogen. While many synthetic models of [Fe]-hydrogenase have been prepared, none yet are capable of activating H-2 on their own. Here, we re ...
American Chemical Society2016A Novel Nickel Pincer Complex in the Active Site of Lactate Racemase
A recent study revealed the structure of the Ni-containing active site of lactate racemase. The Ni is coordinated by a SCS pincer ligand derived from a nicotinic acid mononucleotide. ...
Wiley-Blackwell2016Identification of HcgC as a SAM-Dependent Pyridinol Methyltransferase in [Fe]-Hydrogenase Cofactor Biosynthesis
Previous retrosynthetic and isotope-labeling studies have indicated that biosynthesis of the iron guanylylpyridinol (FeGP) cofactor of [Fe]-hydrogenase requires a methyltransferase. This hypothetical enzyme covalently attaches the methyl group at the 3-pos ...
Wiley-Blackwell2016Reconstitution of [Fe]-hydrogenase using model complexes
Xile Hu, Matthew Wodrich, Tao Xu, Dafa Chen
[Fe]-Hydrogenase catalyses the reversible hydrogenation of a methenyltetrahydromethanopterin substrate, which is an intermediate step during the methanogenesis from CO2 and H-2. The active site contains an iron-guanylylpyridinol cofactor, in which Fe2+ is ...
Nature Publishing Group2015