Publications by Murat Kaynak | EPFL Graph Search

Colloidal self-assembly of soft neural interfaces from injectable photovoltaic microdevices

Mahmut Selman Sakar, Zhangjun Huang, Murat Kaynak, Haiyan Jia

Biomimetic retinas with a wide field of view and high resolution are in demand for neuroprosthetics and robot vision. Conventional neural prostheses are manufactured outside the application area and implanted as a complete device using invasive surgery. He ...

2023

3D Printed Acoustically Programmable Soft Microactuators

Mahmut Selman Sakar, Murat Kaynak, Amit Yedidia Dolev

The concept of creating all-mechanical soft microrobotic systems has great potential to address outstanding challenges in biomedical applications, and introduce more sustainable and multifunctional products. To this end, magnetic fields and light have been ...

2023

Dynamics of entrapped microbubbles with multiple openings

Mahmut Selman Sakar, Murat Kaynak, Amit Yedidia Dolev

Microbubbles excited by acoustic fields inside water oscillate, and generate acoustic radiation forces and drag-induced acoustic streaming. These forces can be harnessed in various biomedical applications such as targeted drug delivery and on-chip biomanip ...

2022

Microengineered devices enable long-term imaging of the ventral nerve cord in behaving adult Drosophila

Mahmut Selman Sakar, Pavan P Ramdya, Florian Aymanns, Victor Lobato Rios, Murat Kaynak, Semih Günel, Chin-Lin Chen, Laura Joan Hermans, Jonas Friedrich Braun

The dynamics and connectivity of neural circuits continuously change on timescales ranging from milliseconds to an animal's lifetime. Therefore, to understand biological networks, minimally invasive methods are required to repeatedly record them in behavin ...

Nature Research2022

Development of soft microscopic implants and acoustically-powered machines for biomedical applications

Murat Kaynak

The development of miniaturized machines that can actively cross barriers, navigate through heterogeneous materials and access remote sites can revolutionize environmental inspection and targeted therapy. Seminal work demonstrated the feasibility of follow ...

EPFL2021

Cancer-cell stiffening via cholesterol depletion enhances adoptive T-cell immunotherapy

Georg Fantner, Mahmut Selman Sakar, Li Tang, Lucia Bonati, Murat Kaynak, Mélanie Thérèse Marie Hannebelle, Yugang Guo, Yuqing Xie, Min Gao, Armand Kurum

Cancer cells enriched in cholesterol in their plasma membrane impair T-cell-mediated cytotoxicity, which can be augmented by stiffening the cancer cells via cholesterol depletion, as shown in mouse models of adoptive T-cell immunotherapy. Malignant transfo ...

2021

On-Board Mechanical Control Systems for Untethered Microrobots

Mahmut Selman Sakar, Murat Kaynak, Amit Yedidia Dolev

2021

Addressable Acoustic Actuation of 3D Printed Soft Robotic Microsystems

Mahmut Selman Sakar, Murat Kaynak, Pietro Luciano Jakobus Dirix

A design, manufacturing, and control methodology is presented for the transduction of ultrasound into frequency-selective actuation of multibody hydrogel mechanical systems. The modular design of compliant mechanisms is compatible with direct laser writing ...

2020

BAF restricts cGAS on nuclear DNA to prevent innate immune activation

Mahmut Selman Sakar, Beat Fierz, Andrea Ablasser, Baptiste Claude André Guey, Alexiane Clara Decout, Murat Kaynak, Kristina Makasheva, Marilena Wischnewski

The appearance of DNA in the cytosol is perceived as a danger signal that stimulates potent immune responses through cyclic guanosine monophosphate–adenosine monophosphate synthase (cGAS). How cells regulate the activity of cGAS toward self-DNA and guard a ...

American Association for the Advancement of Science2020

Modular soft robotic microdevices for dexterous biomanipulation

Francesco Stellacci, Mahmut Selman Sakar, Ece Özelçi, Ahmet Bekdemir, Murat Kaynak, Berna Ayse Özkale Edelmann, Raquel Filipa Penacho Parreira, Lucio Feo Pancaldi-Giubbini

We present a methodology for building biologically inspired, soft microelectromechanical systems (MEMS) devices. Our strategy combines several advanced techniques including programmable colloidal self-assembly, light-harvesting with plasmonic nanotransduce ...

2019