Publications related to Small-scale bioreactor system for process development and optimization

Numerical Modeling of the Conjugate Heat Transfer Problem for Annular Laminar Film Condensation in Microchannels

This paper presents numerical simulations of annular laminar film condensation heat transfer in micro-channels of different internal shapes. The model, which is based on a finite volume formulation of the Navier-Stokes and energy equations for the liquid p ...

American Soc Mechanical Engineers, Three Park Avenue, New York, Ny 10016-5990 Usa2009

Two-Phase Modeling of Hot Tearing in Aluminum Alloys: Applications of a Semicoupled Method

Michel Rappaz, Vincent Mathier, Stéphane Vernède

Hot tearing formation in both a classical tensile test and during direct chill (DC) casting of aluminum alloys has been modeled using a semicoupled, two-phase approach. Following a thermal calculation, the deformation of the mushy solid is computed using a ...

2009

Orbitally shaken bioreactors for mammalian cell culture

Xiaowei Zhang

Driven by the commercial success of recombinant biopharmaceuticals, there is an increasing demand for novel, cost-effective mammalian cell culture bioreactor systems for the production of biologicals requiring mammalian protein processing. Recently, orbita ...

EPFL2009

Three-Phase Catalytic Hydrogenation of a Functionalized Alkyne: Mass Transfer and Kinetic Studies with in Situ Hydrogen Monitoring

Albert Renken, Lioubov Kiwi, Martin Grasemann

Systematic studies of mass transfer interactions with intrinsic reaction kinetics were performed for the threephase selective hydrogenation of 2-methyl-3-butyn-2-ol (MBY) to 2-methyl-3-buten-2-ol (MBE) over a modified Pd/CaC

{O}_{3}

catalyst under solvent ...

2008

Crystallization of the resonating valence bond liquid as vortex condensation

Frédéric Mila, Dmitri Ivanov

We show that the liquid-to-crystal quantum phase transition in the Rokhsar-Kivelson dimer model on the two-dimensional triangular lattice occurs as a condensation of vortexlike excitations called "visons." This conclusion is drawn from numerical studies of ...

2007

Two-Dimensional Magnetic Droplet Manipulation Platform for Miniaturized Bioanalytical Applications

Martinus Gijs, Ulrike Lehmann, Virendra Kumar Parashar, Caroline Vandevyver

We present a new approach for the manipulation of small liquid samples for the miniaturization of bioanalytical systems. In our system, minute liquid volumes are manipulated via the interaction of a changeable magnetic field and magnetic microparticles con ...

2007

Paraffin-PDMS composite thermo microactuator with large vertical displacement capability

Nico de Rooij, Danick Briand, Herbert Shea

We have micromachined and tested the first paraffinPDMS composite thermal microactuator having multi shot large vertical displacement capabilities ( 160 um for 1 mm diameter device). A solid to liquid phase change of trapped paraffin into the PDMS is used ...

2006

Scanning probe arrays for life sciences and nanobiology applications

Nico de Rooij, Terunobu Akiyama, Peter Vettiger, Laure Aeschimann, André Meister

Various 1D and 2D scanning probe arrays with integrated piezoresistive sensors have been developed in view of nanobiology and life science applications. For such applications, the experiments need usually to be performed under liquid conditions. The probe ...

2006

Ultrasonic measurements in ice slurry generation by direct contact evaporation

Didier Albert Simon Vuarnoz

Important reductions of refrigerant amounts can be achieved by using secondary refrigeration fluids. Ice slurry is a two-phase fluid and thus, compared to single phase secondary refrigeration fluids, offers the advantage of the latent heat of fusion when t ...

2004

Individually addressable gel-integrated voltammetric microelectrode array for high-resolution measurement of concentration profiles at interfaces

The application of a novel voltammetric probe, based on an individually addressable gel-integrated microelectrode array (IA-GIME), for real-time, high-spatial resolution concentration profile measurements at interfaces is described. Reliability and validit ...

2001

Small-scale bioreactor system for process development and optimization

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Numerical Modeling of the Conjugate Heat Transfer Problem for Annular Laminar Film Condensation in Microchannels

Two-Phase Modeling of Hot Tearing in Aluminum Alloys: Applications of a Semicoupled Method

Orbitally shaken bioreactors for mammalian cell culture

Three-Phase Catalytic Hydrogenation of a Functionalized Alkyne: Mass Transfer and Kinetic Studies with in Situ Hydrogen Monitoring

Crystallization of the resonating valence bond liquid as vortex condensation

Two-Dimensional Magnetic Droplet Manipulation Platform for Miniaturized Bioanalytical Applications

Paraffin-PDMS composite thermo microactuator with large vertical displacement capability

Scanning probe arrays for life sciences and nanobiology applications

Ultrasonic measurements in ice slurry generation by direct contact evaporation

Individually addressable gel-integrated voltammetric microelectrode array for high-resolution measurement of concentration profiles at interfaces

Two-Phase Modeling of Hot Tearing in Aluminum Alloys: Applications of a Semicoupled Method

Orbitally shaken bioreactors for mammalian cell culture

Three-Phase Catalytic Hydrogenation of a Functionalized Alkyne: Mass Transfer and Kinetic Studies with in Situ Hydrogen Monitoring

Individually addressable gel-integrated voltammetric microelectrode array for high-resolution measurement of concentration profiles at interfaces

Scanning probe arrays for life sciences and nanobiology applications

Crystallization of the resonating valence bond liquid as vortex condensation

Numerical Modeling of the Conjugate Heat Transfer Problem for Annular Laminar Film Condensation in Microchannels

Two-Dimensional Magnetic Droplet Manipulation Platform for Miniaturized Bioanalytical Applications

Paraffin-PDMS composite thermo microactuator with large vertical displacement capability

Ultrasonic measurements in ice slurry generation by direct contact evaporation