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A virtual valve for smooth contamination-free flow switching

Related publications (34)

System for automated and dynamic cell culture

The present relates to a system for automated cell culture, the system comprising an inflow module, a cell culture plate and an outflow module, said inflow module being in fluid connection with the outflow module via the cell culture plate, the inflow modu ...

2023

A Strategy to Conjugate Bioactive Fragments to Cytotoxic Diiron Bis(cyclopentadienyl) Complexes

Paul Joseph Dyson, Mouna Hadiji, Silvia Schoch, Sarah Alexandra Pais Pereira

A series of bioactive molecules were synthesized from the condensation of aspirin or chlorambucil with terminal alkynes bearing alcohol or amine substituents. Insertion of the resulting alkynes into the iron-carbyne bond of readily accessible diiron bis(cy ...

AMER CHEMICAL SOC2021

Genetically encoded betaxanthin-based small-molecular fluorescent reporter for mammalian cells

Leo Scheller, Karl Gademann, Simon Sieber

We designed and engineered a dye production cassette encoding a heterologous pathway, including human tyrosine hydroxylase and Amanita muscaria 4,5-DOPA dioxygenase, for the biosynthesis of the betaxanthin family of plant and fungal pigments in mammalian c ...

2020

Dielectric Elastomer Actuator for Mechanical Loading of 2D Cell Cultures

Herbert Shea, Samuel Rosset, Alexandre Poulin

We demonstrate the use of dielectric elastomer actuators (DEAs) for mechanical stimulation of cells in vitro. The development of living tissues is regulated by their mechanical environment through the modification of fundamental cellular functions such as ...

Royal Society of Chemistry2016

Enzyme SU-8 microreactors: simple tools for cell-culture monitoring

Nico de Rooij, Peter Van der Wal, Sara Talaei, Martha Liley

Monitoring metabolism fluctuations inside a cell culture is a valuable method for assessment of the cells vitality. Enzyme-based biosensors can provide selective measurement of metabolites such as glucose, lactate, glutamate and choline. However, integrati ...

Springer Verlag2015

Shedding Light on Living Cells

Diego Ghezzi

An overview of the optical methods available to modulate the cellular activity in cell cultures and biological tissues is presented, with a focus on the use of exogenous functional materials that absorb electromagnetic radiation and transduce it into a sec ...

Wiley-Blackwell2014

Design, development, and validation of an in-situ biosensor array for metabolite monitoring of cell cultures

Giovanni De Micheli, Sandro Carrara, Jacopo Olivo, Cristina Boero, Marco Mazza, Maria Antonietta Casulli, Lorenzo Foglia

Conventional pharmaceutical processes involving cell culture growth are generally taken under control with expensive and long laboratory tests performed by direct sampling to evaluate quality. This traditional and well-established approach is just partiall ...

Elsevier2014

Spatiotemporal Intracellular Nitric Oxide Signaling Captured Using Internalized, Near-Infrared Fluorescent Carbon Nanotube Nanosensors

Ardemis Anoush Boghossian, Xun Gong

Fluorescent nanosensor probes have suffered from limited mol. recognition and a dearth of strategies for spatial-temporal operation in cell culture. In this work, we spatially imaged the dynamics of nitric oxide (NO) signaling, important in numerous pathol ...

2014

Impedance spectroscopy for in vitro toxicology

Robert Meissner

The impedance of biological material changes with frequency, a phenomenon that has been discovered more than 100 years ago. It is due to the fact that the cell membrane acts as a capacitor which filters out currents at low frequency and lets them pass at h ...

EPFL2013

Scleractinian coral cell proliferation is reduced in primary culture of suspended multicellular aggregates compared to polyps

Anders Meibom, Shirit Cohen, Isabelle Domart-Coulon, Agathe Eliette Marie Lecointe

Cell cultures from reef-building scleractinian corals are being developed to study the response of these ecologically important organisms to environmental stress and diseases. Despite the importance of cell division to support propagation, cell proliferati ...

Springer2013

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