Publications related to A Polyoxyethylene-Substituted Bimetallic Europium Helicate for Luminescent Staining of Living Cells

Adverse Effects of Industrial Multiwalled Carbon Nanotubes on Human Pulmonary Cells

The aim of this study was to evaluate adverse effects of multiwalled carbon nanotubes (MWCNT), produced for industrial purposes, on the human epithelial cell line A549. MWCNT were dispersed in dipalmitoyl lecithin (DPL), a component of pulmonary surfactant ...

2009

Chromosomal Number Aberrations and Transformation in Adult Mouse Retinal Stem Cells In Vitro

Freddy Radtke, Ivan Stamenkovic

Purpose. The potential of stem cells (SCs) as a source for cell-based therapy on a wide range of degenerative diseases and damaged tissues such as retinal degeneration has been recognized. Generation of a high number of retinal stem cells (RSCs) in vitro w ...

2009

Tuning the anticancer activity of maltol-derived ruthenium complexes by derivatization of the 3-hydroxy-4-pyrone moiety

Paul Joseph Dyson, Christian Hartinger, Alexey Nazarov

Aldol reaction of allomaltol with arom. aldehydes, e.g., RC6H4CHO, R = H, 4-NO2, 4-F, 2-F and 3,4,5-(MeO)3C5H2CHO, gave 2-(hydroxyphenylmethyl)-3-hydroxy-6-methylpyran-4(1)-ones, maltol-derived ligands. Organometallic Ru(II)-arene complexes, [RuCl2(cymene) ...

2009

A Versatile Ditopic Ligand System for Sensitizing the Luminescence of Bimetallic Lanthanide Bio-Imaging Probes

Jean-Claude Bünzli, Anne-Sophie Chauvin, Caroline Vandevyver, Bo Song, Steve Comby

The homoditopic ligand 6,6’- [methylenebis(1-methyl-1H-benzimid- azole-5,2-diyl)]bis(4-{2-[2-(2-methoxy- ethoxy)ethoxy]ethoxy}pyridine-2-carboxylic acid) (H2LC2) has been tailored to self-assemble with lanthanide ions (LnIII), which results in the formatio ...

2008

Effect of the length of polyoxyethylene substituents on luminescent bimetallic lanthanide bioprobes

Jean-Claude Bünzli, Anne-Sophie Chauvin, Caroline Vandevyver, Bo Song

The new homoditopic ligand

H_2L^{C2'}

self-assembles with lanthanide ions (

Ln^{III}

) to yield neutral bimetallic helicates of overall composition

[Ln_2(L^{C2'})_3]

; it is fitted with two hexakis(oxyethylene) chains to test their effects on the thermo ...

2008

Luminescent lanthanides bioprobes emitting in the visible and/or near-infrared ranges

Steve Comby

This Ph.D. work deals with the development of lanthanide-based bioprobes for biomedical analyses and imaging. For this purpose, two different approaches have been followed, one focusing on visible-emitting complexes, while the second addresses the sensitiz ...

EPFL2008

Lanthanide Bimetallic Helicates for in Vitro Imaging and Sensing

Jean-Claude Bünzli, Anne-Sophie Chauvin, Caroline Vandevyver, Bo Song, Steve Comby

As the need for targeting luminescent biolabels increases, for mapping selected analytes, imaging of cells and organs, and tracking in cellulo processes, lanthanide bimetallic helicates are emerging as versatile bioprobes. The wrapping of three ligand stra ...

2008

In vitro anticancer activity and biologically relevant metabolization of organometallic ruthenium complexes with carbohydrate-based ligands

Paul Joseph Dyson, Christian Hartinger, Alexey Nazarov, Olivier Pierre Zava, Michael Groessl, Frédéric Schmitt, Muhammad Hanif

The synthesis and in vitro anticancer activity of dihalo(η6-p-cymene)(3,5,6-bicyclophosphite-α-D-glucofuranoside)ruthenium(II) complexes are described. The compds. were characterized by NMR spectroscopy and ESI mass spectrometry, and the mol. structures of ...

2008

Effect of cell media on polymer coated superparamagnetic iron oxide nanoparticles (SPIONs): Colloidal stability, cytotoxicity, and cellular uptake studies

Heinrich Hofmann, Jatuporn Salaklang, Alke Fink, Benedikt Steitz, Andrija Finka

The influence of the composition of the polymer coated polyvinyl alcohol (PVA), vinyl alcohol/vinyl amine copolymer (A-PVA) and polyethylenimine (PEI) coated superparamagnetic iron oxide nanoparticles (SPIONs) on the colloidal stability, cytotoxicity and c ...

2008

Importance of the p-Ligand: Remarkable Effect of the Cyclopentadienyl Ring on the Cytotoxicity of Ruthenium PTA Compounds

Paul Joseph Dyson, Rosario Scopelliti, Kay Severin, Claudine Scolaro, Barnali Dutta

The water-sol. complexes [(Cp'OR)RuCl(PTA)2] (Cp'OR = h5-1-alkoxy-2,4-di-tert-butyl-3-neopentylcyclopentadienyl; R = Me, Et; PTA = 1,3,5-triaza-7-phosphaadamantane) are considerably more cytotoxic (.apprx.2 orders of magnitude) than the cyclopentadienyl an ...

2008

A Polyoxyethylene-Substituted Bimetallic Europium Helicate for Luminescent Staining of Living Cells

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Adverse Effects of Industrial Multiwalled Carbon Nanotubes on Human Pulmonary Cells

Chromosomal Number Aberrations and Transformation in Adult Mouse Retinal Stem Cells In Vitro

Tuning the anticancer activity of maltol-derived ruthenium complexes by derivatization of the 3-hydroxy-4-pyrone moiety

A Versatile Ditopic Ligand System for Sensitizing the Luminescence of Bimetallic Lanthanide Bio-Imaging Probes

Effect of the length of polyoxyethylene substituents on luminescent bimetallic lanthanide bioprobes

Luminescent lanthanides bioprobes emitting in the visible and/or near-infrared ranges

Lanthanide Bimetallic Helicates for in Vitro Imaging and Sensing

In vitro anticancer activity and biologically relevant metabolization of organometallic ruthenium complexes with carbohydrate-based ligands

Effect of cell media on polymer coated superparamagnetic iron oxide nanoparticles (SPIONs): Colloidal stability, cytotoxicity, and cellular uptake studies

Importance of the p-Ligand: Remarkable Effect of the Cyclopentadienyl Ring on the Cytotoxicity of Ruthenium PTA Compounds

Tuning the anticancer activity of maltol-derived ruthenium complexes by derivatization of the 3-hydroxy-4-pyrone moiety

Luminescent lanthanides bioprobes emitting in the visible and/or near-infrared ranges

Chromosomal Number Aberrations and Transformation in Adult Mouse Retinal Stem Cells In Vitro

A Versatile Ditopic Ligand System for Sensitizing the Luminescence of Bimetallic Lanthanide Bio-Imaging Probes

Adverse Effects of Industrial Multiwalled Carbon Nanotubes on Human Pulmonary Cells

Effect of cell media on polymer coated superparamagnetic iron oxide nanoparticles (SPIONs): Colloidal stability, cytotoxicity, and cellular uptake studies

In vitro anticancer activity and biologically relevant metabolization of organometallic ruthenium complexes with carbohydrate-based ligands

Lanthanide Bimetallic Helicates for in Vitro Imaging and Sensing

Effect of the length of polyoxyethylene substituents on luminescent bimetallic lanthanide bioprobes

Importance of the p-Ligand: Remarkable Effect of the Cyclopentadienyl Ring on the Cytotoxicity of Ruthenium PTA Compounds