Publications related to Early diabetes and abnormal postnatal pancreatic islet development in mice lacking Glut-2

Towards high resolution optical imaging of beta cells in vivo

Theo Lasser, Anne Grapin-Botton, Martin Villiger, Joan Goulley, Erica Martin-Williams

Endocrine beta cells produce and release insulin in order to tightly regulate glucose homeostasis and prevent metabolic pathologies such as Diabetes Mellitus. Optical imaging has contributed greatly to our current understanding of beta cell structure and f ...

Bentham Science Publishers2010

PPAR gamma Ligands Switched High Fat Diet-Induced Macrophage M2b Polarization toward M2a Thereby Improving Intestinal Candida Elimination

Johan Auwerx

Obesity is associated with a chronic low-grade inflammation that predisposes to insulin resistance and the development of type 2 diabetes. In this metabolic context, gastrointestinal (GI) candidiasis is common. We recently demonstrated that the PPAR gamma ...

Public Library of Science2010

Beta amyloid and hyperphosphorylated tau deposits in the pancreas in type 2 diabetes

László Forró, Aleksandra Radenovic, Andras Kis

Strong epidemiologic evidence suggests an association between Alzheimer disease (AD) and type 2 diabetes. To determine if amyloid beta (A

\beta

) and hyperphosphorylated tau occurs in type 2 diabetes, pancreas tissues from 21 autopsy cases (10 type 2 diabe ...

Elsevier2010

The transcription factor Rfx3 regulates beta-cell differentiation, function, and glucokinase expression

Philipp Bucher

OBJECTIVE: Pancreatic islets of perinatal mice lacking the transcription factor Rfx3 exhibit a marked reduction in insulin-producing beta-cells. The objective of this work was to unravel the cellular and molecular mechanisms underlying this deficiency. RES ...

American Diabetes Association2010

Wnt Signaling in Pancreas Development and Cancer

During early somite stages of development, the broad endoderm-derived foregut and hindgut territories become further subdivided along the antero-posterior axis into organs. One of these organs is the pancreas which serves two major physiological functions: ...

EPFL2010

Neurochemical changes in the developing rat hippocampus during prolonged hypoglycemia

Rolf Gruetter, Ramachandra Rao

Hypoglycemia is common during development and is associated with the risk of neurodevelopmental deficits in human infants. The effects of hypoglycemia on the developing hippocampus are poorly understood. The sequential changes in energy substrates, amino a ...

Wiley-Blackwell2010

The gait and balance of patients with diabetes can be improved: a randomised controlled trial

Kamiar Aminian, Stéphane Armand

Gait characteristics and balance are altered in diabetic patients. Little is known about possible treatment strategies. This study evaluates the effect of a specific training programme on gait and balance of diabetic patients. ...

2010

Targeting the TGR5-GLP-1 pathway to combat type 2 diabetes and non-alcoholic fatty liver disease

Johan Auwerx, Kristina Schoonjans, Thijs Pols

Incretin-based therapies have shown promise in the treatment of type 2 diabetes. Here we review our current understanding of TGR5 as a target to induce glucagon-like peptide-1 (GLP-1) secretion. These new observations suggest that TGR5 agonists may constit ...

Elsevier Masson2010

Role of Neurogenin3 in migration of pancreatic endocrine cells during development

Mathieu Gouzi

The pancreas is one of the major organs of the digestive tract. Its endocrine function, mainly regulating glucose blood level, is achieved by endocrine cells. These cells are organized in clusters, the so-called islets of Langerhans. During development, th ...

EPFL2010

Molecular selective interface for an implantable glucose sensor based on the viscosity variation of a sensitive fluid containing dextran and Concanavalin A

Antoine Barraud

Diabetes mellitus is a globally growing disease with more than 180 million cases worldwide and no cure exists. In order to minimize the many medical complications, tight glucose monitoring has been shown to be the best alternative. Many diabetics require i ...

EPFL2009

Early diabetes and abnormal postnatal pancreatic islet development in mice lacking Glut-2

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Towards high resolution optical imaging of beta cells in vivo

PPAR gamma Ligands Switched High Fat Diet-Induced Macrophage M2b Polarization toward M2a Thereby Improving Intestinal Candida Elimination

Beta amyloid and hyperphosphorylated tau deposits in the pancreas in type 2 diabetes

The transcription factor Rfx3 regulates beta-cell differentiation, function, and glucokinase expression

Wnt Signaling in Pancreas Development and Cancer

Neurochemical changes in the developing rat hippocampus during prolonged hypoglycemia

The gait and balance of patients with diabetes can be improved: a randomised controlled trial

Targeting the TGR5-GLP-1 pathway to combat type 2 diabetes and non-alcoholic fatty liver disease

Role of Neurogenin3 in migration of pancreatic endocrine cells during development

Molecular selective interface for an implantable glucose sensor based on the viscosity variation of a sensitive fluid containing dextran and Concanavalin A

Wnt Signaling in Pancreas Development and Cancer

Role of Neurogenin3 in migration of pancreatic endocrine cells during development

Neurochemical changes in the developing rat hippocampus during prolonged hypoglycemia

Towards high resolution optical imaging of beta cells in vivo

The gait and balance of patients with diabetes can be improved: a randomised controlled trial

Targeting the TGR5-GLP-1 pathway to combat type 2 diabetes and non-alcoholic fatty liver disease

Molecular selective interface for an implantable glucose sensor based on the viscosity variation of a sensitive fluid containing dextran and Concanavalin A

Beta amyloid and hyperphosphorylated tau deposits in the pancreas in type 2 diabetes

The transcription factor Rfx3 regulates beta-cell differentiation, function, and glucokinase expression

PPAR gamma Ligands Switched High Fat Diet-Induced Macrophage M2b Polarization toward M2a Thereby Improving Intestinal Candida Elimination