Publication
Control of colinearity in AbdB genes of the mouse HoxD complex
Related publications (35)
Coordinated Hoxd genes expression during embryogenesis is dependent on a strict disposition of genes and polarized regulators within the HoxD cluster
HOX transcription factors determine the identity of body regions along the rostro-caudal axis during bilaterian embryogenesis. In vertebrates Hox genes distinctively lie organized in dense clusters, each typically composed of a dozen paralogous transcripti ...
EPFL2018Heterogeneous combinatorial expression of Hoxd genes in single cells during limb development
Denis Duboule, Marion Leleu, Pierre Raymond Fabre
Background: Global analyses of gene expression during development reveal specific transcription patterns associated with the emergence of various cell types, tissues, and organs. These heterogeneous patterns are instrumental to ensure the proper formation ...
BMC2018The HoxD cluster is a dynamic and resilient TAD boundary controlling the segregation of antagonistic regulatory landscapes.
Denis Duboule, Lucille Delisle, Pierre Raymond Fabre, Leonardo Beccari, Edgardo Rodriguez Carballo
The mammalian HoxD cluster lies between two topologically associating domains (TADs) matching distinct enhancer-rich regulatory landscapes. During limb development, the telomeric TAD controls the early transcription of Hoxd genes in forearm cells, whereas ...
Cold Spring Harbor Laboratory Press2017A role for HOX13 proteins in the regulatory switch between TADs at the HoxD locus
Denis Duboule, Leonardo Beccari, Anamaria Necsulea, Nicolas Lonfat, Edgardo Rodriguez Carballo, Nayuta Yakushiji
During vertebrate limb development, Hoxd genes are regulated following a bimodal strategy involving two topologically associating domains (TADs) located on either side of the gene cluster. These regulatory landscapes alternatively control different subsets ...
Cold Spring Harbor Laboratory2016Control of Hoxd gene transcription in the mammary bud by hijacking a preexisting regulatory landscape
Denis Duboule, Jozsef Zakany, Guillaume Andrey, Leonardo Beccari, Anamaria Necsulea, Edgardo Rodriguez Carballo, Virginie Marcet
Vertebrate Hox genes encode transcription factors operating during the development of multiple organs and structures. However, the evolutionary mechanism underlying this remarkable pleiotropy remains to be fully understood. Here, we show that Hoxd8 and Hox ...
National Academy of Sciences2016An ancestral regulatory mechanism underlies Hoxd gene expression in both developing genitals and digits
Coordinated expression of HoxD cluster genes is crucial for the emergence and patterning of both developing digits and external genitalia. As a shared evolutionary origin has been proposed for these secondary structures, which may have accompanied the tran ...
EPFL2013Multiple Enhancers Regulate Hoxd Genes and the Hotdog LncRNA during Cecum Budding
Denis Duboule, Marion Leleu, Saskia Joëlle Delpretti Anex
Hox genes are required for the development of the intestinal cecum, a major organ of plant-eating species. We have analyzed the transcriptional regulation of Hoxd genes in cecal buds and show that they are controlled by a series of enhancers located in a g ...
Elsevier2013Polycomb Recruitment and Targeting in Mammals
Polycomb- (PcG) and trithorax (trxG) group proteins are essential components in the regulation of multiple developmental regulators. In particular, during early stages, they act as chromatin modifiers in such a way as to set and maintain the transcriptiona ...
EPFL2013A switch between topological domains underlies HoxD genes collinearity in mouse limbs
Didier Trono, Denis Duboule, Marion Leleu, Daniël Noordermeer, Guillaume Andrey
Hox genes are major determinants of the animal body plan, where they organize structures along both the trunk and appendicular axes. During mouse limb development, Hoxd genes are transcribed in two waves: early on, when the arm and forearm are specified, a ...
Amer Assoc Advancement Science2013Analysis of the dynamics of limb transcriptomes during mouse development
Denis Duboule, Felix Naef, István Gyurján
ABSTRACT: BACKGROUND: The development of vertebrate limbs has been a traditional system to study fundamental processes at work during ontogenesis, such as the establishment of spatial cellular coordinates, the effect of diffusible morphogenetic molecules o ...
BioMed Central2011