Publications related to Preventive and/or therapeutic agents for diabetes

Metabolic Alterations Associated to Brain Dysfunction in Diabetes

From epidemiological studies it is known that diabetes patients display increased risk of developing dementia. Moreover, cognitive impairment and Alzheimer's disease (AD) are also accompanied by impaired glucose homeostasis and insulin signalling. Although ...

Int Soc Aging & Disease2015

TGR5 reduces macrophage migration through mTOR-induced C/EBP beta differential translation

Kristina Schoonjans, Alessia Perino, Matthias Alexander Sokrates Stein, Mitsunori Nomura, Thijs Pols

The bile acid-responsive G protein-coupled receptor TGR5 is involved in several metabolic processes, and recent studies suggest that TGR5 activation may promote pathways that are protective against diet-induced diabetes. Here, we investigated the role of m ...

American Society for Clinical Investigation2014

The gait and balance of patients with diabetes can be improved: a randomised controlled trial

Kamiar Aminian, Stéphane Armand

Gait characteristics and balance are altered in diabetic patients. Little is known about possible treatment strategies. This study evaluates the effect of a specific training programme on gait and balance of diabetic patients. ...

2010

Beta amyloid and hyperphosphorylated tau deposits in the pancreas in type 2 diabetes

László Forró, Aleksandra Radenovic, Andras Kis

Strong epidemiologic evidence suggests an association between Alzheimer disease (AD) and type 2 diabetes. To determine if amyloid beta (A

\beta

) and hyperphosphorylated tau occurs in type 2 diabetes, pancreas tissues from 21 autopsy cases (10 type 2 diabe ...

Elsevier2010

Targeting the TGR5-GLP-1 pathway to combat type 2 diabetes and non-alcoholic fatty liver disease

Johan Auwerx, Kristina Schoonjans, Thijs Pols

Incretin-based therapies have shown promise in the treatment of type 2 diabetes. Here we review our current understanding of TGR5 as a target to induce glucagon-like peptide-1 (GLP-1) secretion. These new observations suggest that TGR5 agonists may constit ...

Elsevier Masson2010

In vivo imaging of murine endocrine islets of Langerhans with extended-focus optical coherence microscopy

Theo Lasser, Michael Friedrich, Rainer Leitgeb, Anne Grapin-Botton, Martin Villiger, Joan Goulley

Aims/hypothesis Structural and functional imaging of the islets of Langerhans and the insulin-secreting beta cells represents a significant challenge and a long-lasting objective in diabetes research. In vivo microscopy offers a valuable insight into beta ...

Springer Verlag2009

Induction of brain aquaporin 9 (AQP9) in catecholaminergic neurons in diabetic rats

Pierre Magistretti, Jean-Marie Petit

Aquaporin 9 facilitates the diffusion of water but also glycerol and monocarboxylates, known as brain energy substrates. AQP9 was recently observed in catecholaminergic neurons that are implicated in energy homeostasis and also possibly in neuroendocrine e ...

2008

Brain glucose concentrations in poorly controlled diabetes mellitus as measured by high-field magnetic resonance spectroscopy

Rolf Gruetter

Hyperglycemia and diabetes alter the function and metabolism of many tissues. The effect on the brain remains poorly defined, but some animal data suggest that chronic hyperglycemia reduces rates of brain glucose transport and/or metabolism. To address thi ...

Elsevier2005

Nuclear receptors and the control of metabolism

Johan Auwerx

The metabolic nuclear receptors act as metabolic and toxicological sensors, enabling the organism to quickly adapt to environmental changes by inducing the appropriate metabolic genes and pathways. Ligands for these metabolic receptors are compounds from d ...

2003

Endogenous expression levels of autoantigens influence success or failure of DNA immunizations to prevent type 1 diabetes: addition of IL-4 increases safety

Steinunn Baekkeskov Hanahan

Administration of autoantigens through DNA immunizations or via the oral route can prevent progression of islet destruction and lower the incidence of type 1 diabetes in animal models. This beneficial effect is mediated by autoreactive regulatory CD4 lymph ...

Wiley-Blackwell2002

Preventive and/or therapeutic agents for diabetes

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Metabolic Alterations Associated to Brain Dysfunction in Diabetes

TGR5 reduces macrophage migration through mTOR-induced C/EBP beta differential translation

The gait and balance of patients with diabetes can be improved: a randomised controlled trial

Beta amyloid and hyperphosphorylated tau deposits in the pancreas in type 2 diabetes

Targeting the TGR5-GLP-1 pathway to combat type 2 diabetes and non-alcoholic fatty liver disease

In vivo imaging of murine endocrine islets of Langerhans with extended-focus optical coherence microscopy

Induction of brain aquaporin 9 (AQP9) in catecholaminergic neurons in diabetic rats

Brain glucose concentrations in poorly controlled diabetes mellitus as measured by high-field magnetic resonance spectroscopy

Nuclear receptors and the control of metabolism

Endogenous expression levels of autoantigens influence success or failure of DNA immunizations to prevent type 1 diabetes: addition of IL-4 increases safety

Beta amyloid and hyperphosphorylated tau deposits in the pancreas in type 2 diabetes

TGR5 reduces macrophage migration through mTOR-induced C/EBP beta differential translation

Targeting the TGR5-GLP-1 pathway to combat type 2 diabetes and non-alcoholic fatty liver disease

The gait and balance of patients with diabetes can be improved: a randomised controlled trial

Brain glucose concentrations in poorly controlled diabetes mellitus as measured by high-field magnetic resonance spectroscopy

In vivo imaging of murine endocrine islets of Langerhans with extended-focus optical coherence microscopy

Endogenous expression levels of autoantigens influence success or failure of DNA immunizations to prevent type 1 diabetes: addition of IL-4 increases safety

Induction of brain aquaporin 9 (AQP9) in catecholaminergic neurons in diabetic rats

Nuclear receptors and the control of metabolism

Metabolic Alterations Associated to Brain Dysfunction in Diabetes