Publication

Surface biopassivation of replicated poly(dimethylsiloxane) microfluidic channels and application to heterogeneous immunoreaction with on-chip fluorescence detection

Related publications (46)

Individual particle handling in a microfluidic system based on parallel laser trapping

René Salathé, Horst Vogel, Peter Ryser, Michael Werner, Bastien Rachet, Mathieu Grossenbacher

We present an optical trapping system combining individually addressable multiple laser traps with fluorescence spectroscopy. An in-line set of 64 near-IR laser diodes is used to create a line of individually addressable traps inside a microfluidic chip. T ...

Optical Society of America2011

Microfluidic device for analysis of protein biomarkers using magnetic bead surface coverage detection

Martinus Gijs, Hüseyin Cumhur Tekin, Cynthia Scherz

We present a microfluidic device for on-chip analysis of low-concentration protein biomarkers. A new detection method, based on the magnetic capture of proteins via superparamagnetic beads and counting the surface coverage of the latter is presented. The p ...

2011

UV-Curable Glue (NOA81) for Fabrication of a Closed Microfluidic Channel with Hydrophilic and Hydrophobic Surfaces

Nico de Rooij, Philip Wägli

Polymers like PDMS or SU-8 have become popular for microfluidic applications. We show that modifications of the surface energy are more stable on NOA81 compared to PDMS. A simple method to fabricate a closed all-polymer microfluidic channel showing both hy ...

2011

Microfluidic Protein Preconcentrator Using a Microchannel-Integrated Nafion Strip: Experiment and Modeling

Martinus Gijs, Venkataragavalu Sivagnanam, Meng Shen

We propose a simple microfluidic device for protein preconcentration based on the electrokinetic trapping principle. It comprises a narrow Nafion strip that is simply cut from a commercial membrane and is integrated into a molded poly(dimethylsiloxane) (PD ...

American Chemical Society2010

NOA 63 as a UV-curable material for fabrication of microfluidic channels with native hydrophilicity

Martinus Gijs, Raphaelle Luisier, Emile Dupont

In this paper, we propose a method to create a natively hydrophilic microfluidic structure in a fast and simple way using an UV-curable polymer (NOA 63 from Norland Optics). This polymer can provide a substitute to PDMS microchannels offering high reproduc ...

2010

NOA 63 as a UV-curable material for fabrication of microfluidic channels with native hydrophilicity

Martinus Gijs, Raphaelle Luisier, Emile Dupont

2010

Microfluidic assays for DNA manipulation based on a block copolymer immobilization strategy

Demetri Psaltis, Andreas Vasdekis

Methods to manipulate and visualize isolated DNA and oligonucleotide strands are important for investigation of their biophysics as well as their interactions with proteins. Herein, we report such a method by combining a block copolymer surface functionali ...

2010

Norland optical adhesive (NOA81) microchannels with adjustable surface properties and high chemical resistance against IR-transparent organic solvents

Nico de Rooij, Philip Wägli

The optical adhesive NOA81 (Norland Products Inc.) is a promising UV-curable material for low-cost microfluidic applications. We demonstrated that its surface energy can be adjusted by different surface treatments or by mixing an additive in the uncured bu ...

Elsevier Science, Reg Sales Off, Customer Support Dept, 655 Ave Of The Americas, New York, Ny 10010 Usa2010

An automated two-phase microfluidic system for kinetic analyses and the screening of compound libraries

Christoph Merten

Droplet-based microfluidic systems allow biological and chemical reactions to be performed on a drastically decreased scale. However, interfacing the outside world with such systems and generating high numbers of microdroplets of distinct chemical composit ...

2010

Study of Spatio-Temporal Immunofluorescence on Bead Patterns in a Microfluidic Channel

Martinus Gijs, Venkataragavalu Sivagnanam, Hui Yang

We performed a direct immunoassay inside a microfluidic channel on patterned streptavidin-coated beads, which captured fluorescently-labeled biotin target molecules from a continuous flow. We arranged the beads in a dot array at the bottom of the channel a ...

American Institute of Physics2010

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