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Microfluidics-Generated Immobilized Biomolecule Gradients on Hydrogels

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Microfluidic Chips for Point-of-Care Immunodiagnostics

Nico de Rooij, Luc Gervais, Emmanuel Delamarche

We might be at the turning point where research in microfluidics undertaken in academia and industrial research laboratories, and substantially sponsored by public grants, may provide a range of portable and networked diagnostic devices. In this Progress R ...

Wiley-Blackwell2011

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This paper reports on silicon-based microprobes, 8 mm long and 250 mu m x 250 mu m cross-section, comprising four recessed biosensor microelectrodes (50 mu m x 150 mu m) per probe shank coated with an enzymatic layer for the selective detection of choline ...

2011

Simultaneous washing and concentration of functionalized magnetic beads in a complex sample solution was demonstrated by applying a rotational magnetic actuation system to a microfluidic chip under continuous flow conditions. The rotation of periodically a ...

2011

Microfluidic bio-assays have emerged as the most privileged solutions and provide the basis for the realization of miniaturized bio-analytical systems and clinical diagnostic devices that are portable, user-friendly and cost-effective (Lab-on-a-chip). Two ...

EPFL2010

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In this paper, we propose a method to create a natively hydrophilic microfluidic structure in a fast and simple way using an UV-curable polymer (NOA 63 from Norland Optics). This polymer can provide a substitute to PDMS microchannels offering high reproduc ...

2010

NOA 63 as a UV-curable material for fabrication of microfluidic channels with native hydrophilicity

Martinus Gijs, Raphaelle Luisier, Emile Dupont

2010

Formulation of composite resistive pastes for micro-heater manufacturing

Peter Ryser, Thomas Maeder, Nathalie Sophie Adeline Serra, Pierre Lemaire

We investigate in this work the formulation of composite resistive pastes based on epoxy resins and graphite for micro-heater manufacturing via thick-film technology. The resistive paste is first screen-printed onto a printed circuit board (PCB) substrate, ...

Elsevier2009

The covalent attachment of adhesion molecules to silicone membranes for cell stretching applications

Jean-Jacques Meister, Hicham Majd, Boris Hinz, Lara Buscemi Estefanell, Pierre Jean Arnould Wipff

Strain devices with expandable polydimethylsiloxane (PDMS) culture membranes are frequently used to stretch cells in vitro, mimicking mechanically dynamic tissue environments. To immobilize cell-adhesive molecules to the otherwise non-adhesive PDMS substra ...

Elsevier2009

We use microfluidic devices to encapsulate, incubate, and manipulate individual cells in picoliter aqueous drops in a carrier fluid at rates of up to several hundred Hz. We use a modular approach with individual devices for each function, thereby significa ...

2008

Optical trapping and micromanipulation of biological objects in microfluidic channels

Marinela Gjoni Boillat

The main aim of this project was to develop novel concepts for miniaturization of bioanalytical techniques for investigating biomolecular interactions. We used optical tweezers to selectively address individual biological objects in microfluidic channels. ...

EPFL2007