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COMBINE: An Improved Directory-Based Consistency Protocol

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Differentiated consistency for worldwide gossips

Davide Frey, Pierre-Louis Blaise Roman

Eventual consistency is a consistency model that favors liveness over safety. It is often used in large-scale distributed systems where models ensuring a stronger safety incur performance that are too low to be deemed practical. Eventual consistency tends ...

2022

A Rosetta-based protein design protocol converging to natural sequences

Bruno Emanuel Ferreira De Sousa Correia, Zander Harteveld, Stéphane Rosset, Giulia Sormani

Computational protein design has emerged as a powerful tool capable of identifying sequences compatible with pre-defined protein structures. The sequence design protocols, implemented in the Rosetta suite, have become widely used in the protein engineering ...

AMER INST PHYSICS2021

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Modern online services are shifting away from monolithic applications to loosely-coupled microservices because of their improved scalability, reliability, programmability and development velocity. Microservices communicating over the datacenter network req ...

ACM2020

R2P2: Making RPCs first-class datacenter citizens

Edouard Bugnion, Evangelos Marios Kogias, Adrien Ghosn, Georgios Prekas, Jonas Fietz

Remote Procedure Calls are widely used to connect datacenter applications with strict tail-latency service level objectives in the scale of µs. Existing solutions utilize streaming or datagram-based transport protocols for RPCs that impose overheads and li ...

USENIX ASSOC2019

One-Pot Synthesis of 1-[(Triisopropylsilyl)ethynyl]-1,2-benziodoxol-3(1H)-one (TIPS-EBX): Process Safety Assessment and Impact of Impurities on Product Stability

Jérôme Waser, Stefano Nicolai, Miyeon Chang, Durga Prasada Rao Hari, Paola Caramenti, Lionel Schouwey

The hypervalent iodine reagent 1-[(TriIsoPropylSilyl)Ethynyl]-1,2-BenziodoXol-3(1H)-one (TIPS-EBX) is among the most useful electrophilic and somophilic alkynylation reagents. Herein, we report a new synthetic protocol to access this reagent in one step fr ...

2019

Creating Secrets Out Of Packet Erasures

Christina Fragouli, László Czap, Iris Safaka

We present protocols for creating pairwise secrets between nodes in a wireless network, so that these secrets are secure from an eavesdropper, Eve, with unbounded computational and memory capabilities, but with limited network presence. We first present a ...

Ieee-Inst Electrical Electronics Engineers Inc2016

Scale-out non-uniform memory access

Babak Falsafi, Edouard Bugnion, Boris Robert Grot, Alexandros Daglis, Stanko Novakovic

A computing system that uses a Scale-Out NUMA (“soNUMA”) architecture, programming model, and/or communication protocol provides for low-latency, distributed in-memory processing. Using soNUMA, a programming model is layered directly on top of a NUMA memor ...

2015

Scale-Out NUMA

Babak Falsafi, Edouard Bugnion, Boris Robert Grot, Alexandros Daglis, Stanko Novakovic

Emerging datacenter applications operate on vast datasets that are kept in DRAM to minimize latency. The large number of servers needed to accommodate this massive memory footprint requires frequent server-to-server communication in applications such as ke ...

2014

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Scaling to a large number of cores with non-uniform communication latency and unpredictable response time may call for viewing a modern many-core architecture as a distributed system. In this view, the cores replicate shared data and ensure consistency amo ...

2014

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ACM Press2014