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Calcium dynamics and vasomotion in arteries subject to isometric, isobaric, and isotonic conditions

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Acute RyR1 Ca2+ leak enhances NADH-linked mitochondrial respiratory capacity

Johan Auwerx, Umberto De Marchi

Sustained ryanodine receptor (RyR) Ca2+ leak is associated with pathological conditions such as heart failure or skeletal muscle weakness. We report that a single session of sprint interval training (SIT), but not of moderate intensity continuous training ...

NATURE PORTFOLIO2021

Mathematical and numerical models for the cardiac electromechanical function

Alfio Quarteroni, Francesco Regazzoni

This paper deals with the mathematical model that describes the function of the human heart. More specifically, it addresses the equations that express the electromechanical process, that is the mechanical deformation (contraction and relaxation) of the he ...

EUROPEAN MATHEMATICAL SOC-EMS2021

Background and Aim:Drumming requires excellent motor control and temporal coordination. Deploying specific muscle activation patterns may help achieve these requirements. Muscle activation patterns that involve reciprocal contraction of antagonist muscles ...

FRONTIERS MEDIA SA2020

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Mathematical modeling of the human heart and its function can expand our understanding of various cardiac diseases, which remain the most common cause of death in the developed world. Like other physiological systems, the heart can be understood as a compl ...

Elsevier Science Sa2017

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In this paper, we study the blood flow dynamics in a three-dimensional (3D) idealized left ventricle of the human heart whose deformation is driven by muscle contraction and relaxation in coordination with the action of the mitral and aortic valves. We pro ...

MATHICSE2017

Amer Inst Physics2017

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Mathematical modelling of the human heart and its function can expand our understanding of various cardiac diseases, which remain the most common cause of death in the developed world. Like other physiological systems, the heart can be understood as a comp ...

MATHICSE2016

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Test assays capable of providing quantitative characterization of the contraction of cardiac and smooth muscle cells are of great need for drug development and screening. Several methodologies have been proposed for achieving measurement of cell contractil ...

Elsevier Science Bv2016

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We consider the numerical simulation of integrated heart models for the study of the cardiac functioning with particular emphasis on the coupling of the muscle contraction, the fluid dynamics of the left ventricle, and the interaction with the valves. We a ...

CMBE, Zeta Computational Resources Ltd.2015

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The development of thin-film dielectric elastomer strain sensors for the characterization of smooth muscle cell (SMC) contraction is presented here. Smooth muscle disorders are an integral part of diseases such as asthma and emphysema. Analytical tools ena ...

Spie-Int Soc Optical Engineering2015