Publication

One-pot synthesis of macrocycles by a tandem three-component reaction and intramolecular [3+2] cycloaddition

Jieping Zhu
2006
Journal paper

Abstract

By combining three appropriately designed simple substrates, a programmed sequence involving an alpha -isocyano acetamide-based three-component reaction followed by a copper-catalyzed intramol. [3+2] cycloaddn. of alkyne and azide took place to afford complex macrocycles, e.g., I, in moderate to good yields. One macrocycle and two heterocycles were produced with concurrent formation of five chem. bonds in this operationally simple process. [on SciFinder (R)]

Official source

https://infoscience.epfl.ch/record/158087?ln=en

About this result

This page is automatically generated and may contain information that is not correct, complete, up-to-date, or relevant to your search query. The same applies to every other page on this website. Please make sure to verify the information with EPFL's official sources.

Graph Chatbot

Chat with Graph Search

Ask any question about EPFL courses, lectures, exercises, research, news, etc. or try the example questions below.

DISCLAIMER: The Graph Chatbot is not programmed to provide explicit or categorical answers to your questions. Rather, it transforms your questions into API requests that are distributed across the various IT services officially administered by EPFL. Its purpose is solely to collect and recommend relevant references to content that you can explore to help you answer your questions.

One-pot synthesis of macrocycles by a tandem three-component reaction and intramolecular [3+2] cycloaddition

Graph Chatbot

Chat with Graph Search

Generative power of a protein language model trained on multiple sequence alignments

Combining phylogeny and coevolution improves the inference of interaction partners among paralogous proteins

Generative power of a protein language model trained on multiple sequence alignments

Combining phylogeny and coevolution improves the inference of interaction partners among paralogous proteins