Publication
By combining three appropriately designed simple substrates, a programmed sequence involving an alpha -isocyano acetamide-based three-component reaction followed by a copper-catalyzed intramol. [3+2] cycloaddn. of alkyne and azide took place to afford complex macrocycles, e.g., I, in moderate to good yields. One macrocycle and two heterocycles were produced with concurrent formation of five chem. bonds in this operationally simple process. [on SciFinder (R)]
Anne-Florence Raphaëlle Bitbol
Anne-Florence Raphaëlle Bitbol, Damiano Sgarbossa, Umberto Lupo
John Maddocks, Daiva Petkeviciute, Rahul Sharma, Marco Pasi, Paolo Carloni