Publication
The invention concerns a 5-aminolevulinic acid ester (I) soln. for producing a pharmaceutical prepn. useful for diagnosing and/or treating tissue and/or cell pathologies by local radiation exposure using radiation emitted by a light source energy followed, in the case of diagnosis, by detection of fluorescent protoporphyrin IX (II). The I concn. in said soln. is less than 1% and ranges between 0.01% and 0.5%. Said low I concn. in the soln. increases II synthesis and homogenizes its distribution in the cell layers while highly reducing the secondary toxicity for the treated cells (no data).
Anja Skrivervik, Stéphanie Lacour, Zvonimir Sipus, Mingxiang Gao, German Augusto Ramirez Arroyave, Kangling Wu