Cyclinac Medical Accelerators Using Pulsed C6+/H2+ Ion Sources

Alberto Degiovanni, Adriano Garonna
2010
Journal paper

Abstract

Charged particle therapy, or so-called hadrontherapy, is developing very rapidly. There is large pressure on the scientific community to deliver dedicated accelerators, providing the best possible treatment modalities at the lowest cost. In this context, the Italian research Foundation TERA is developing fast-cycling accelerators, dubbed 'cyclinacs'. These are a combination of a cyclotron (accelerating ions to a fixed initial energy) followed by a high gradient linac boosting the ions energy up to the maximum needed for medical therapy. The linac is powered by many independently controlled klystrons to vary the beam energy from one pulse to the next. This accelerator is best suited to treat moving organs with a 4D multi-painting spot scanning technique. A dual proton/carbon ion cyclinac is here presented. It consists of an Electron Beam Ion Source, a superconducting isochronous cyclotron and a high-gradient linac. All these machines are pulsed at high repetition rate (100-400 Hz). The source should deliver both C6+ and H2+ ions in short pulses (1.5 {\mu}s flat-top) and with sufficient intensity (at least 108 fully stripped carbon ions at 300 Hz). The cyclotron accelerates the ions to 120 MeV/u. It features a compact design (with superconducting coils) and a low power consumption. The linac has a novel C-band high gradient structure and accelerates the ions to variable energies up to 400 MeV/u. High RF frequencies lead to power consumptions which are much lower than the ones of synchrotrons for the same ion extraction energy. This work is part of a collaboration with the CLIC group, which is working at CERN on high-gradient electron-positron colliders.

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Alberto Degiovanni, Adriano Garonna
2010
Journal paper

Abstract

Official source

https://infoscience.epfl.ch/record/165807?ln=en

About this result

Related concepts (16)

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Related publications

Cyclinac medical accelerators using pulsed C6+/H + 2 ion sources

Alberto Degiovanni, Adriano Garonna

Charged particle therapy, or so-called hadrontherapy, is developing very rapidly. There is large pressure on the scientific community to deliver dedicated accelerators, providing the best possible treatment modalities at the lowest cost. In this context, the Italian research Foundation TERA is developing fast-cycling accelerators, dubbed 'cyclinacs'. These are a combination of a cyclotron (accelerating ions to a fixed initial energy) followed by a high gradient linac boosting the ions energy up to the maximum needed for medical therapy. The linac is powered by many independently controlled klystrons to vary the beam energy from one pulse to the next. This accelerator is best suited to treat moving organs with a 4D multipainting spot scanning technique. A dual proton/carbon ion cyclinac is here presented. It consists of an Electron Beam Ion Source, a superconducting isochronous cyclotron and a high-gradient linac. All these machines are pulsed at high repetition rate (100-400 Hz). The source should deliver both C6+ and H+ 2 ions in short pulses (1.5 μs flat-top) and with sufficient intensity (at least 10 8 fully stripped carbon ions per pulse at 300 Hz). The cyclotron accelerates the ions to 120 MeV/u. It features a compact design (with superconducting coils) and a low power consumption. The linac has a novel C-band high-gradient structure and accelerates the ions to variable energies up to 400 MeV/u. High RF frequencies lead to power consumptions which are much lower than the ones of synchrotrons for the same ion extraction energy. This work is part of a collaboration with the CLIC group, which is working at CERN on high-gradient electron-positron colliders. © 2010 IOP Publishing Ltd and SISSA.

2010

Cyclotron Designs for Ion Beam Therapy with Cyclinacs

Adriano Garonna

This thesis presents new superconducting compact (as opposed to separated-sector ) cyclotron designs for injection in CABOTO, a linac developed by the TERA Foundation delivering C6+/H2+ beams up to 400 MeV/u for ion beam therapy. This association of a variable energy linac injected by a fixed energy cyclotron is called cyclinac. Two superconducting cyclotron designs are compared under the same design constraints and methods: a synchrocyclotron and an isochronous cyclotron, both at the highest possible magnetic field and with an output energy of 230 MeV/u. This energy allows to use the cyclotron as a stand-alone accelerator for protontherapy. Once the optimal cyclotron is determined, lower energy cyclotrons can easily be designed. The short pulse length (1.5 µs), fast repetition rate (100-300 Hz) and small beam transmission of the cyclinac (0.2%) require intense pulsed ion sources. To deliver the desired clinical dose rate, the average pulse current of 60 eµA of C6+ at 300 Hz can be produced by three commercial EBIS (EBIS-SC by Dreebit Gmbh) operating at 100 Hz and connected to the beamline in alternating mode. A multicusp ion source is sufficient to produce compatible H2+ beams. The synchrocyclotron design features a central magnetic field of 5 T, an axisymmetric pole and a constant field index of 0.02. The beam is injected axially with a spiral inflector (K = 1.4). A static magnetic perturbation of 0.1 T and 5° width boosts the beam radial gain per turn (with no emittance degradation) by exciting the first radial integer resonance and thus allows beam ejection with moderate beam losses (30%). The RF system operates in first harmonic (Q = 2500). The 180° Dee provides 28 kV peak voltage and the RF is modulated (30-38 MHz) by a rotating capacitor (90-900 pF). The synchrocyclotron's best features are the simple and compact magnet (300 tons) and the low RF power requirements (30 kW power supply). The isochronous cyclotron design features a 3.2 T central magnetic field, four sectors and a pole characterized by elliptical gaps in the hills (3-30 mm) and in the valleys (11-50 cm). Spiraling is minimized (80° total hill axis rotation) and beam ejection is achieved with a single electrostatic deflector placed inside an empty valley. The two RF cavities operate in fourth harmonic at 98 MHz (Q = 7100). The RF system provides peak voltages of 70-120 kV and is powered by a single 100 kW unit. The synchrocyclotron reliability is brought into question by the need of a rotating capacitor and by the complexity of the injection and ejection systems. However, the isochronous cyclotron requires a much more complex magnet. Overall, the isochronous cyclotron is a better solution compared to the synchrocyclotron, because it is as compact but more reliable. To quantitatively determine the industrial and clinical optimum for the CABOTO injection energy, three complementary isochronous cyclotrons of 70, 120 and 170 MeV/u are studied, based on the 230 MeV/u design. The optimal cyclotron energy strongly depends on the clinical aim of the facility. For a dual proton and carbon ion centre, the best compromise between clinical flexibility, accelerator size and power consumption is to accelerate particles up to 150 MeV/u in the cyclotron. In this configuration, the 150 MeV/u isochronous cyclotron has similar weight and spiraling as the most widely used cyclotron for protontherapy (C235 by IBA S.A.), CABOTO is 24 m long and the overall power consumption of the cyclinac is 650 kW. Adding to these characteristics, the property of fast energy variation of the linac makes the cyclinac presented in this thesis a strongly competitive accelerator for dual proton and carbon ion therapy.

EPFL2011

Hadron therapy refers to a medical treatment that uses hadron beams (i.e. protons and ions) to deliver localized energy that suppresses cancerous cells, sparing the neighbouring healthy tissues from unwanted radiation. The major technical components of a hadron therapy centre are the particle accelerator (cyclotron, synchrotron, or linac) and the beam delivery system that controls, shapes and orients the particles towards the area to be treated. The beam delivery can consist of fixed transfer lines, or it can include a gantry, a transfer line that rotates around the patient and allows radiation from multiple directions. The present work investigates a new toroidal gantry for hadron therapy, named GaToroid. This novel gantry configuration allows the dose delivery from a discrete number of angles avoiding magnets as well as patient rotation. Compared to traditional gantries that require rotating magnets, this improvement is made possible by a toroidal magnet operating in steady-state. This design constitutes the ideal conditions for the use of superconductors to generate a significantly higher magnetic field compared to normal-conducting solutions, as well as to reduce the weight and footprint of the magnets. The study of a GaToroid system requires the integration of several aspects of physics and engineering. In this framework, the focus of this research is on the design of the superconducting coils integrated with beam optics and particle tracking analyses. The first part of the thesis illustrates the optimization of the toroidal magnet. Coupling two-dimensional particle tracking and magnetic field calculations, an algorithm was developed to identify optimal gantry configurations that maximize the energy acceptance of the system. Two solutions composed of 16 coils, differing in high and low values of engineering current density, were investigated. In line with current clinical requirements, the beams converged at the isocenter within 1 mm over the whole treatment energy spectrum for both configurations. The second part of the thesis describes the algorithm implemented for the two- and three-dimensional particle tracking. Building upon the results of the magnetic optimization, a linear beam optics formalism was developed to determine the focusing properties of GaToroid. The third part of the thesis focuses on the engineering design of the low current density solution. Using two thermo-electric models, lumped and one-dimensional, the Nb-Ti and ReBCO cable geometries were validated, together with the quench protection system. Furthermore, analytical and numerical studies on mechanics made it possible to estimate the overall footprint and weight of the system. Results show that, compared with the state-of-the-art gantries, the proposed GaToroid solution has the potential to be more compact and lighter by at least a factor two. Finally, the last part of the thesis describes the design of a scaled-down demonstrator wound with ReBCO tapes. Studies on quench protection, mechanics and experimental implementation aimed at testing the use of ReBCO technology for GaToroid coils are discussed. In conclusion, this work presents the first overall description of a GaToroid system, ranging from the analytical definition, magnetic optimization, particle tracking and magnet engineering. The investigation of this new toroidal paradigm for gantries represents a quantum step toward more compact and less expensive solutions for hadron therapy centres.

EPFL2021

Cyclotron Designs for Ion Beam Therapy with Cyclinacs

Adriano Garonna

EPFL2011