Publication
Reconstructed ancestral sequences improve pathogen identification using resequencing DNA microarrays
Related concepts (33)
Bisulfite sequencing
Bisulfite sequencing (also known as bisulphite sequencing) is the use of bisulfite treatment of DNA before routine sequencing to determine the pattern of methylation. DNA methylation was the first discovered epigenetic mark, and remains the most studied. In animals it predominantly involves the addition of a methyl group to the carbon-5 position of cytosine residues of the dinucleotide CpG, and is implicated in repression of transcriptional activity.
Human genome
The human genome is a complete set of nucleic acid sequences for humans, encoded as DNA within the 23 chromosome pairs in cell nuclei and in a small DNA molecule found within individual mitochondria. These are usually treated separately as the nuclear genome and the mitochondrial genome. Human genomes include both protein-coding DNA sequences and various types of DNA that does not encode proteins. The latter is a diverse category that includes DNA coding for non-translated RNA, such as that for ribosomal RNA, transfer RNA, ribozymes, small nuclear RNAs, and several types of regulatory RNAs.
Lp space
DISPLAYTITLE:Lp space In mathematics, the Lp spaces are function spaces defined using a natural generalization of the p-norm for finite-dimensional vector spaces. They are sometimes called Lebesgue spaces, named after Henri Lebesgue , although according to the Bourbaki group they were first introduced by Frigyes Riesz . Lp spaces form an important class of Banach spaces in functional analysis, and of topological vector spaces.
Accuracy and precision
Accuracy and precision are two measures of observational error. Accuracy is how close a given set of measurements (observations or readings) are to their true value, while precision is how close the measurements are to each other. In other words, precision is a description of random errors, a measure of statistical variability. Accuracy has two definitions: More commonly, it is a description of only systematic errors, a measure of statistical bias of a given measure of central tendency; low accuracy causes a difference between a result and a true value; ISO calls this trueness.
Multiple sequence alignment
Multiple sequence alignment (MSA) may refer to the process or the result of sequence alignment of three or more biological sequences, generally protein, DNA, or RNA. In many cases, the input set of query sequences are assumed to have an evolutionary relationship by which they share a linkage and are descended from a common ancestor. From the resulting MSA, sequence homology can be inferred and phylogenetic analysis can be conducted to assess the sequences' shared evolutionary origins.
Countably compact space
In mathematics a topological space is called countably compact if every countable open cover has a finite subcover. A topological space X is called countably compact if it satisfies any of the following equivalent conditions: (1) Every countable open cover of X has a finite subcover. (2) Every infinite set A in X has an ω-accumulation point in X. (3) Every sequence in X has an accumulation point in X. (4) Every countable family of closed subsets of X with an empty intersection has a finite subfamily with an empty intersection.
Sequence homology
Sequence homology is the biological homology between DNA, RNA, or protein sequences, defined in terms of shared ancestry in the evolutionary history of life. Two segments of DNA can have shared ancestry because of three phenomena: either a speciation event (orthologs), or a duplication event (paralogs), or else a horizontal (or lateral) gene transfer event (xenologs). Homology among DNA, RNA, or proteins is typically inferred from their nucleotide or amino acid sequence similarity.
Separable extension
In field theory, a branch of algebra, an algebraic field extension is called a separable extension if for every , the minimal polynomial of over F is a separable polynomial (i.e., its formal derivative is not the zero polynomial, or equivalently it has no repeated roots in any extension field). There is also a more general definition that applies when E is not necessarily algebraic over F. An extension that is not separable is said to be inseparable.
Group extension
In mathematics, a group extension is a general means of describing a group in terms of a particular normal subgroup and quotient group. If and are two groups, then is an extension of by if there is a short exact sequence If is an extension of by , then is a group, is a normal subgroup of and the quotient group is isomorphic to the group . Group extensions arise in the context of the extension problem, where the groups and are known and the properties of are to be determined.
Infection
An infection is the invasion of tissues by pathogens, their multiplication, and the reaction of host tissues to the infectious agent and the toxins they produce. An infectious disease, also known as a transmissible disease or communicable disease, is an illness resulting from an infection. Infections can be caused by a wide range of pathogens, most prominently bacteria and viruses. Hosts can fight infections using their immune systems. Mammalian hosts react to infections with an innate response, often involving inflammation, followed by an adaptive response.