Multi-parametric surface plasmon resonanceMulti-parametric surface plasmon resonance (MP-SPR) is based on surface plasmon resonance (SPR), an established real-time label-free method for biomolecular interaction analysis, but it uses a different optical setup, a goniometric SPR configuration. While MP-SPR provides same kinetic information as SPR (equilibrium constant, dissociation constant, association constant), it provides also structural information (refractive index, layer thickness). Hence, MP-SPR measures both surface interactions and nanolayer properties.
Interleukin 6Interleukin 6 (IL-6) is an interleukin that acts as both a pro-inflammatory cytokine and an anti-inflammatory myokine. In humans, it is encoded by the IL6 gene. In addition, osteoblasts secrete IL-6 to stimulate osteoclast formation. Smooth muscle cells in the tunica media of many blood vessels also produce IL-6 as a pro-inflammatory cytokine. IL-6's role as an anti-inflammatory myokine is mediated through its inhibitory effects on TNF-alpha and IL-1 and its activation of IL-1ra and IL-10.
CytokineCytokines are a broad and loose category of small proteins (~5–25 kDa) important in cell signaling. Due to their size, cytokines cannot cross the lipid bilayer of cells to enter the cytoplasm and therefore typically exert their functions by interacting with specific cytokine receptors on the target cell surface. Cytokines have been shown to be involved in autocrine, paracrine and endocrine signaling as immunomodulating agents.
Surface plasmon polaritonSurface plasmon polaritons (SPPs) are electromagnetic waves that travel along a metal–dielectric or metal–air interface, practically in the infrared or visible-frequency. The term "surface plasmon polariton" explains that the wave involves both charge motion in the metal ("surface plasmon") and electromagnetic waves in the air or dielectric ("polariton"). They are a type of surface wave, guided along the interface in much the same way that light can be guided by an optical fiber.
Poincaré dualityIn mathematics, the Poincaré duality theorem, named after Henri Poincaré, is a basic result on the structure of the homology and cohomology groups of manifolds. It states that if M is an n-dimensional oriented closed manifold (compact and without boundary), then the kth cohomology group of M is isomorphic to the ()th homology group of M, for all integers k Poincaré duality holds for any coefficient ring, so long as one has taken an orientation with respect to that coefficient ring; in particular, since every manifold has a unique orientation mod 2, Poincaré duality holds mod 2 without any assumption of orientation.
InflammationInflammation (from inflammatio) is part of the complex biological response of body tissues to harmful stimuli, such as pathogens, damaged cells, or irritants, and is a protective response involving immune cells, blood vessels, and molecular mediators. The function of inflammation is to eliminate the initial cause of cell injury, clear out necrotic cells and tissues damaged from the original insult and the inflammatory process, and initiate tissue repair.
AutoimmunityIn immunology, autoimmunity is the system of immune responses of an organism against its own healthy cells, tissues and other normal body constituents. Any disease resulting from this type of immune response is termed an "autoimmune disease". Prominent examples include celiac disease, post-infectious IBS, diabetes mellitus type 1, Henoch–Schönlein purpura (HSP) sarcoidosis, systemic lupus erythematosus (SLE), Sjögren syndrome, eosinophilic granulomatosis with polyangiitis, Hashimoto's thyroiditis, Graves' disease, idiopathic thrombocytopenic purpura, Addison's disease, rheumatoid arthritis (RA), ankylosing spondylitis, polymyositis (PM), dermatomyositis (DM), and multiple sclerosis (MS).
Verdier dualityIn mathematics, Verdier duality is a cohomological duality in algebraic topology that generalizes Poincaré duality for manifolds. Verdier duality was introduced in 1965 by as an analog for locally compact topological spaces of Alexander Grothendieck's theory of Poincaré duality in étale cohomology for schemes in algebraic geometry. It is thus (together with the said étale theory and for example Grothendieck's coherent duality) one instance of Grothendieck's six operations formalism.
PlasmonIn physics, a plasmon is a quantum of plasma oscillation. Just as light (an optical oscillation) consists of photons, the plasma oscillation consists of plasmons. The plasmon can be considered as a quasiparticle since it arises from the quantization of plasma oscillations, just like phonons are quantizations of mechanical vibrations. Thus, plasmons are collective (a discrete number) oscillations of the free electron gas density. For example, at optical frequencies, plasmons can couple with a photon to create another quasiparticle called a plasmon polariton.
Serre dualityIn algebraic geometry, a branch of mathematics, Serre duality is a duality for the coherent sheaf cohomology of algebraic varieties, proved by Jean-Pierre Serre. The basic version applies to vector bundles on a smooth projective variety, but Alexander Grothendieck found wide generalizations, for example to singular varieties. On an n-dimensional variety, the theorem says that a cohomology group is the dual space of another one, . Serre duality is the analog for coherent sheaf cohomology of Poincaré duality in topology, with the canonical line bundle replacing the orientation sheaf.
