Folding funnelThe folding funnel hypothesis is a specific version of the energy landscape theory of protein folding, which assumes that a protein's native state corresponds to its free energy minimum under the solution conditions usually encountered in cells. Although energy landscapes may be "rough", with many non-native local minima in which partially folded proteins can become trapped, the folding funnel hypothesis assumes that the native state is a deep free energy minimum with steep walls, corresponding to a single well-defined tertiary structure.
Surface energyIn surface science, surface free energy (also interfacial free energy or surface energy) quantifies the disruption of intermolecular bonds that occurs when a surface is created. In solid-state physics, surfaces must be intrinsically less energetically favorable than the bulk of the material (the atoms on the surface have more energy compared with the atoms in the bulk), otherwise there would be a driving force for surfaces to be created, removing the bulk of the material (see sublimation).
PlayStation 3The PlayStation 3 (PS3) is a home video game console developed and marketed by Sony Interactive Entertainment. The successor to the PlayStation 2, it is part of the PlayStation brand of consoles. It was first released on November 11, 2006, in Japan, November 17, 2006, in North America, and March 23, 2007, in Europe and Australia. The PlayStation 3 competed primarily against Microsoft's Xbox 360 and Nintendo's Wii as part of the seventh generation of video game consoles.
Unix timeCurrent Unix time () Unix time is a date and time representation widely used in computing. It measures time by the number of seconds that have elapsed since 00:00:00 UTC on 1 January 1970, the Unix epoch, without adjustments made due to leap seconds. In modern computing, values are sometimes stored with higher granularity, such as microseconds or nanoseconds. Unix time originated as the system time of Unix operating systems. It has come to be widely used in other computer operating systems, , programming languages, and databases.
Time standardA time standard is a specification for measuring time: either the rate at which time passes or points in time or both. In modern times, several time specifications have been officially recognized as standards, where formerly they were matters of custom and practice. An example of a kind of time standard can be a time scale, specifying a method for measuring divisions of time. A standard for civil time can specify both time intervals and time-of-day.
Universal TimeUniversal Time (UT or UT1) is a time standard based on Earth's rotation. While originally it was mean solar time at 0° longitude, precise measurements of the Sun are difficult. Therefore, UT1 is computed from a measure of the Earth's angle with respect to the International Celestial Reference Frame (ICRF), called the Earth Rotation Angle (ERA, which serves as a modern replacement for Greenwich Mean Sidereal Time). UT1 is the same everywhere on Earth. UT1 is required to follow the relationship ERA = 2π(0.
Coordinate timeIn the theory of relativity, it is convenient to express results in terms of a spacetime coordinate system relative to an implied observer. In many (but not all) coordinate systems, an event is specified by one time coordinate and three spatial coordinates. The time specified by the time coordinate is referred to as coordinate time to distinguish it from proper time.
PlayStationis a video gaming brand that consists of five home video game consoles, two handhelds, a media center, and a smartphone, as well as an online service and multiple magazines. The brand is produced by Sony Interactive Entertainment, a division of Sony; the first PlayStation console was released in Japan in December 1994, and worldwide the following year. The original console in the series was the first console of any type to ship over 100 million units, doing so in under a decade.
Serine hydroxymethyltransferaseSerine hydroxymethyltransferase (SHMT) is a pyridoxal phosphate (PLP) (Vitamin B6) dependent enzyme () which plays an important role in cellular one-carbon pathways by catalyzing the reversible, simultaneous conversions of L-serine to glycine and tetrahydrofolate (THF) to 5,10-Methylenetetrahydrofolate (5,10-CH2-THF). This reaction provides the largest part of the one-carbon units available to the cell.
