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Notch1 regulates angio-supportive bone marrow-derived cells in mice: relevance to chemoresistance

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Emerging paradigms and questions on pro-angiogenic bone marrow-derived myelomonocytic cells

Cancer-related inflammation has emerged in recent years as a major event contributing to tumor angiogenesis, tumor progression and metastasis formation. Bone marrow-derived and inflammatory cells promote tumor angiogenesis by providing endothelial progenit ...

2011

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The G protein-coupled receptor TGR5 has been identified as an important component of the bile acid signaling network, and its activation has been linked to enhanced energy expenditure and improved glycemic control. Here, we demonstrate that activation of T ...

Elsevier2011

Methods for enhancing hematopoietic progenitor cell engraftment

Olaia Maria Naveiras Torres-Quiroga

Described herein are methods for improving engraftment of hematopoietic cells in an individual following hematopoietic progenitor cell transplantation (e.g., via bone marrow or cord blood transplantation). Methods for increasing hematopoietic progenitor ce ...

2010

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BACKGROUND: The Notch pathway is essential for proper epidermal differentiation during embryonic skin development. Moreover, skin specific loss of Notch signaling in the embryo results in skin barrier defects accompanied by a B-lymphoproliferative disease. ...

Public Library of Science2010

Novel determinants of the hematopoietic microenvironment in development and homeostasis

Olaia Maria Naveiras Torres-Quiroga

The promise of regenerative medicine depends on succeeding at generating sufficient amounts of functional, transplantable tissue by reliably differentiating pluripotent stem cells through the paths of ontogeny, or by efficiently expanding adult stem cells ...

Harvard University2009

The role of MYC in bone and in the hematopoietic stem cell niche

Maike Jaworski

The nuclear protein c-Myc is one of the most potent proto-oncogenes described. Its expression is found to be deregulated in more than 50 percent of human cancers, where it has been shown to control a number of biological processes including driving prolife ...

EPFL2009

Bone-marrow adipocytes as negative regulators of the haematopoietic microenvironment

Olaia Maria Naveiras Torres-Quiroga

Osteoblasts and endothelium constitute functional niches that support haematopoietic stem cells in mammalian bone marrow. Adult bone marrow also contains adipocytes, the number of which correlates inversely with the haematopoietic activity of the marrow. F ...

2009

Tie2-expressing monocytes (TEMs): novel targets and vehicles of anticancer therapy?

Michele De Palma

There is a growing interest in understanding the complex interactions between bone marrow-derived myeloid-lineage cells and angiogenesis in tumors. Such interest has been revived recently by the observation that tumor-infiltrating myeloid cells convey proa ...

2009

Hematopoietic Stem Cell Function and Survival Depend on c-Myc and N-Myc Activity

Anne Wilson, Armin Ehninger

Myc activity is emerging as a key element in acquisition and maintenance of stem cell properties. We have previously shown that c-Myc deficiency results in accumulation of defective hematopoietic stem cells (HSCs) due to niche-dependent differentiation def ...

2008

Bioluminescence imaging of calvarial bone repair using bone marrow and adipose tissue-derived mesenchymal stem cells

Jeffrey Alan Hubbell

A combined strategy using bioluminescence imaging, bone densitometry and histology was used to analyze the bone regeneration capacity of human bone marrow (hBMSC) and adipose tissue (hAMSC) mesenchymal stem cells, seeded in an osteoconductive arginine-glyc ...

2008