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Protein phosphatase 1 regulates the histone code for long-term memory
Related publications (220)
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Epigenetics plays an important role in cancer development and progression. Cancer cells hijack the epigenome by modifying the histone protein units responsible for packaging DNA, or by modifying the DNA itself, resulting in changes to chromatin topology an ...
EPFL2019Integrated microfluidic tools for the characterization of protein/DNA interactions in vitro and in vivo
The specific interaction between DNA and proteins constitutes one of the crucial elements in the regulation of gene expression. This thesis focuses on the development and optimization of two microfluidic-based technologies called SMiLE-seq and FloChIP that ...
EPFL2019Constitutive differences in glucocorticoid responsiveness are related to divergent spatial information processing abilities
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AMER SOC HEMATOLOGY2019A Dissection of Oligomerization by the TRIM28 Tripartite Motif and the Interaction with Members of the Krab-ZFP Family
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TRIM28 (also known as KAP1 or TIF1β) is the universal co-repressor of the Krüppel-associated box-containing zinc finger proteins (Krab-ZFPs), the largest family of transcription factors in mammals. During early embryogenesis, TRIM28 mediates the transcript ...
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EPFL2019Differential regulation of RNA polymerase III genes during liver regeneration
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Mouse liver regeneration after partial hepatectomy involves cells in the remaining tissue synchronously entering the cell division cycle. We have used this system and H3K4me3, Pol II and Pol III profiling to characterize adaptations in Pol III transcriptio ...
Oxford University Press (OUP)2019Protein Engineering Tools to Explore the Function of Protein Post-Translational Modifications for Chromatin and Microtubule Cytoskeletal Biology
Protein post-translational modifications (PTMs) play a crucial role in expanding the protein diversity and are one of the major mechanisms through which cells respond to ever changing environmental cues. The function of two of the most important cellular c ...
EPFL2019KAP1 is an antiparallel dimer with a functional asymmetry
Didier Trono, Matteo Dal Peraro, Beat Fierz, Davide Demurtas, Maria Josefina Marcaida Lopez, Louise Catherine Bryan, Giulia Fonti, Pierre-Yves Joseph Laurent Helleboid, Alexandra Styliani Kalantzi
KAP1 (KRAB domain-associated protein 1) plays a fundamental role in regulating gene expression in mammalian cells by recruiting different transcription factors and altering the chromatin state. In doing so, KAP1 acts both as a platform for macromolecular i ...
Life Science Alliance, LLC2019