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Changing the responses of cortical neurons from sub- to suprathreshold using single spikes in vivo

Related publications (118)

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The Dynamics of Adapting Neurons

Richard Naud

How do neurons dynamically encode and treat information? Each neuron communicates with its distinctive language made of long silences intermitted by occasional spikes. The spikes are prompted by the pooled effect of a population of pre-synaptic neurons. To ...

EPFL2011

A hybrid bioorganic interface for neuronal photoactivation

Diego Ghezzi

A key issue in the realization of retinal prosthetic devices is reliable transduction of information carried by light into specific patterns of electrical activity in visual information processing networks. Soft organic materials can be used to couple arti ...

2011

Microfabricated Multimode Bio-interface with High Density Microelectrode Array and Photonic Detectors

Mohssen Moridi

Presently, the cells' electrical activity is measured either by extracellular microelectrode array (MEA) or by microscopic fluorescence imaging methods. The MEA is a non-invasive in vitro technique which allows long-term recording at multicellular level wh ...

EPFL2011

Ephaptic coupling of cortical neurons

Henry Markram, Rodrigo de Campos Perin, Constantinos Anastassiou

The electrochemical processes that underlie neural function manifest themselves in ceaseless spatiotemporal field fluctuations. However, extracellular fields feed back onto the electric potential across the neuronal membrane via ephaptic coupling, independ ...

2011

Microchannel electrode interfaces to assess bladder afferent activity

Stéphanie Lacour

By placing axons into polymeric microchannels hosting embedded electrodes the extracellular amplitude of action potentials is greatly increased, allowing for robust recording and noise suppression. We are developing such an electrode interface to record el ...

Ieee Service Center, 445 Hoes Lane, Po Box 1331, Piscataway, Nj 08855-1331 Usa2011

Spike-timing dependent plasticity

Wulfram Gerstner

Spike Timing Dependent Plasticity (STDP) is a temporally asymmetric form of Hebbian learning induced by tight temporal correlations between the spikes of pre- and postsynaptic neurons. As with other forms of synaptic plasticity, it is widely believed that ...

2010

STDP in adaptive neurons gives close-to-optimal information transmission

Wulfram Gerstner, Jean-Pascal Théodor Pfister, Guillaume Hennequin

Spike-frequency adaptation is known to enhance the transmission of information in sensory spiking neurons by rescaling the dynamic range for input processing, matching it to the temporal statistics of the sensory stimulus. Achieving maximal information tra ...

Frontiers Research Foundation2010

Connectivity reflects coding: a model of voltage-based STDP with homeostasis

Wulfram Gerstner, Eleni Vasilaki, Claudia Clopath

Electrophysiological connectivity patterns in cortex often have a few strong connections, which are sometimes bidirectional, among a lot of weak connections. To explain these connectivity patterns, we created a model of spike timing–dependent plasticity (S ...

Nature Publishing Group2010

Membrane potential dynamics of GABAergic neurons in the barrel cortex of behaving mice

Carl Petersen, Michael Avermann, Ferenc Mátyás

Computations in cortical circuits are mediated by synaptic interactions between excitatory and inhibitory neurons, and yet we know little about their activity in awake animals. Here, through single and dual whole-cell recordings combined with two-photon mi ...

Elsevier2010

Complexity and performance in simple neuron models

Wulfram Gerstner, Richard Naud, Skander Mensi

The ability of simple mathematical models to predict the activity of single neurons is important for computational neuroscience. In neurons, stimulated by a time-dependent current or conductance, we want to predict precisely the timing of spikes and the su ...

2010