Publication

Evolving Hox Activity Profiles Govern Diversity in Locomotor Systems

Related publications (34)

Graph Chatbot

Chat with Graph Search

Ask any question about EPFL courses, lectures, exercises, research, news, etc. or try the example questions below.

DISCLAIMER: The Graph Chatbot is not programmed to provide explicit or categorical answers to your questions. Rather, it transforms your questions into API requests that are distributed across the various IT services officially administered by EPFL. Its purpose is solely to collect and recommend relevant references to content that you can explore to help you answer your questions.

A switch between topological domains underlies HoxD genes collinearity in mouse limbs

Didier Trono, Denis Duboule, Marion Leleu, Daniël Noordermeer, Guillaume Andrey

Hox genes are major determinants of the animal body plan, where they organize structures along both the trunk and appendicular axes. During mouse limb development, Hoxd genes are transcribed in two waves: early on, when the arm and forearm are specified, a ...

Amer Assoc Advancement Science2013

Chromatin architectures and hox gene collinearity

Denis Duboule, Daniël Noordermeer

Ever since the observation that collinearity, that is, the sequential activity of Hox genes based on their relative positions within their gene clusters, is conserved throughout most of the animal kingdom, the question has been raised as to what are the un ...

Elsevier Academic Press Inc2013

Duplications of hox gene clusters and the emergence of vertebrates

Denis Duboule

The vertebrate body plan is characterized by an increased complexity relative to that of all other chordates and large-scale gene amplifications have been associated with key morphological innovations leading to their remarkable evolutionary success. Here, ...

Academic Press Inc Elsevier Science2013

Segment number and axial identity in a segmentation clock period mutant.

Andrew Charles Oates

A species-specific number of segments is a hallmark of the vertebrate body plan. The first segmental structures in the vertebrate embryo are the somites, which bud sequentially from the growing presomitic mesoderm (PSM). The Clock and Wavefront model for s ...

2010

Ryczko D, Charrier V, Ijspeert A, Cabelguen JM. Segmental oscillators in axial motor circuits of the salamander: distribution and bursting mechanisms. J Neurophysiol 104: 2677-2692, 2010. First published September 1, 2010; doi:10.1152/jn.00479.2010. The rh ...

American Physiological Society2010

Epigenetic control of hox genes collinear activation during vertebrate development

Denis Duboule

Hox genes encode transcription factors essential for patterning the anterior to posterior animal body axis. In vertebrates, these genes are arranged in clusters. During development, Hox genes are activated in a time sequence that follows their physical ord ...

Elsevier Science BV2009

Epigenetic temporal control of mouse Hox genes in vivo

Denis Duboule

During vertebrate development, the temporal control of Hox gene transcriptional activation follows the genomic order of the genes within the Hox clusters. Although it is recognized that this "Hox clock" serves to coordinate body patterning, the underlying ...

2009

Among living tetrapods, salamanders are regarded as most closely resembling the first terrestrial vertebrates, and are therefore an interesting group in which the evolutionary changes in the locomotor behaviour from aquatic to terrestrial habitats can be i ...

2008

Head-tail patterning of the vertebrate embryo: one, two or many unresolved problems?

Denis Duboule

When, where and how is the head-tail axis of the embryo set up during development? These are such fundamental and intensely studied questions that one might expect them to have been answered long ago. Not so; we still understand very little about the cellu ...

2006

Organizing axes in time and space; 25 years of colinear tinkering

Denis Duboule

During vertebrate development, clustered genes from the Hox family of transcription factors are activated in a precise temporal and spatial sequence that follows their chromosomal order (the "Hox clock"). Recent advances in the knowledge of the underlying ...

2003