Ventricular remodelingIn cardiology, ventricular remodeling (or cardiac remodeling) refers to changes in the size, shape, structure, and function of the heart. This can happen as a result of exercise (physiological remodeling) or after injury to the heart muscle (pathological remodeling). The injury is typically due to acute myocardial infarction (usually transmural or ST segment elevation infarction), but may be from a number of causes that result in increased pressure or volume, causing pressure overload or volume overload (forms of strain) on the heart.
Partial differential equationIn mathematics, a partial differential equation (PDE) is an equation which computes a function between various partial derivatives of a multivariable function. The function is often thought of as an "unknown" to be solved for, similar to how x is thought of as an unknown number to be solved for in an algebraic equation like x2 − 3x + 2 = 0. However, it is usually impossible to write down explicit formulas for solutions of partial differential equations.
Calcium channel blockerCalcium channel blockers (CCB), calcium channel antagonists or calcium antagonists are a group of medications that disrupt the movement of calcium (Ca2+) through calcium channels. Calcium channel blockers are used as antihypertensive drugs, i.e., as medications to decrease blood pressure in patients with hypertension. CCBs are particularly effective against large vessel stiffness, one of the common causes of elevated systolic blood pressure in elderly patients.
Complete theoryIn mathematical logic, a theory is complete if it is consistent and for every closed formula in the theory's language, either that formula or its negation is provable. That is, for every sentence the theory contains the sentence or its negation but not both (that is, either or ). Recursively axiomatizable first-order theories that are consistent and rich enough to allow general mathematical reasoning to be formulated cannot be complete, as demonstrated by Gödel's first incompleteness theorem.
Stiffness matrixIn the finite element method for the numerical solution of elliptic partial differential equations, the stiffness matrix is a matrix that represents the system of linear equations that must be solved in order to ascertain an approximate solution to the differential equation. For simplicity, we will first consider the Poisson problem on some domain Ω, subject to the boundary condition u = 0 on the boundary of Ω. To discretize this equation by the finite element method, one chooses a set of basis functions {φ_1, .
Calcium sparksA calcium spark is the microscopic release of calcium (Ca2+) from a store known as the sarcoplasmic reticulum (SR), located within muscle cells. This release occurs through an ion channel within the membrane of the SR, known as a ryanodine receptor (RyR), which opens upon activation. This process is important as it helps to maintain Ca2+ concentration within the cell. It also initiates muscle contraction in skeletal and cardiac muscles and muscle relaxation in smooth muscles.
