Publications related to Metal Complexes as MRI Contrast Enhancement Agents

Towards the Rational Design of MRI Contrast Agents: Electron Spin Relaxation Is Largely Unaffected by the Coordination Geometry of Gadolinium(III)-DOTA-Type Complexes

Electron-spin relaxation is one of the determining factors in the efficacy of MRI contrast agents. Of all the parameters involved in determining relaxivity it remains the least well understood, particularly as it relates to the structure of the complex. On ...

2008

A benzene-core trinuclear GdIII complex: towards the optimization of relaxivity for MRI contrast agent applications at high magnetic field

André Merbach, Lothar Helm, Eva Jakab Toth, Joao Bruno Livramento Fig.

A novel ligand, H12L, based on a trimethylbenzene core bearing three methylenediethylenetriamine-N,N,N,N- tetraacetate moieties (–CH2DTTA4–) for Gd3+ chelation has been synthesized, and its trinuclear Gd3+ complex [Gd3L(H2O) 6]3– investigated with respect ...

2008

Luminescent lanthanides bioprobes emitting in the visible and/or near-infrared ranges

Steve Comby

This Ph.D. work deals with the development of lanthanide-based bioprobes for biomedical analyses and imaging. For this purpose, two different approaches have been followed, one focusing on visible-emitting complexes, while the second addresses the sensitiz ...

EPFL2008

Lanthanide Bimetallic Helicates for in Vitro Imaging and Sensing

Jean-Claude Bünzli, Anne-Sophie Chauvin, Caroline Vandevyver, Bo Song, Steve Comby

As the need for targeting luminescent biolabels increases, for mapping selected analytes, imaging of cells and organs, and tracking in cellulo processes, lanthanide bimetallic helicates are emerging as versatile bioprobes. The wrapping of three ligand stra ...

2008

Gadonanotubes as Ultrasensitive pH-Smart Probes for Magnetic Resonance Imaging

André Merbach, Lothar Helm, Eva Jakab Toth, Sabrina Laus

With their nanoscalar, superparamagnetic Gd3+-ion clusters (1 ´ 5 nm) confined within ultrashort (20-80 nm) single- walled carbon nanotube capsules, gadonanotubes are high- performance T1-weighted contrast agents for magnetic resonance imaging (MRI). At 1. ...

2008

Effect of the length of polyoxyethylene substituents on luminescent bimetallic lanthanide bioprobes

Jean-Claude Bünzli, Anne-Sophie Chauvin, Caroline Vandevyver, Bo Song

The new homoditopic ligand

H_2L^{C2'}

self-assembles with lanthanide ions (

Ln^{III}

) to yield neutral bimetallic helicates of overall composition

[Ln_2(L^{C2'})_3]

; it is fitted with two hexakis(oxyethylene) chains to test their effects on the thermo ...

2008

In vivo MRI assessment of a novel GdIII-based contrast agent designed for high magnetic field applications

André Merbach, Lothar Helm, Eva Jakab Toth, Joao Bruno Livramento Fig.

Gd3L is a trinuclear Gd3R complex of intermediate size, designed for contrast agent applications in high field magnetic resonance imaging (H12L is based on a trimethylbenzene core bearing three methylene-diethylenetriamine-N,N,N00,N00-tetraacetate moieties ...

2008

Phosphite-derivatized ruthenium-carbohydrate complexes in the catalytic hydration of nitriles

Christian Hartinger, Alexey Nazarov

The synthesis of metal complexes with bioligands is one option to introduce chirally defined ligands to catalysts. Herein, file hydration of nitriles to the corresponding carboxamides by use of ruthenium(H) complexes is described, which were obtained by at ...

2008

Gd(III)-EPTPAC16, a new self-assembling potential liver MRI contrast agent: in vitro characterization and in vivo animal imaging studies

Lothar Helm

The recently reported amphiphilic chelate,

[Gd(EPTPAC_{16})(H_2O)]^{2-}

, forms supramolecular aggregates in aqueous solution by self-assembly of the monomers with a relaxometrically determined critical micellar concentration (CMC) of 0.34 mM. The effect ...

2008

Theoretical investigations of magnetic properties of MRI contrast agents and carbon nanostructures

Oleg Yazyev

The phenomenon of magnetism is one of the key components of today's technological progress. Magnetic interactions and magnetic materials are essential for the scientific disciplines of physics, chemistry and biology, making this subject truly multidiscipli ...

EPFL2007

Metal Complexes as MRI Contrast Enhancement Agents

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Towards the Rational Design of MRI Contrast Agents: Electron Spin Relaxation Is Largely Unaffected by the Coordination Geometry of Gadolinium(III)-DOTA-Type Complexes

A benzene-core trinuclear GdIII complex: towards the optimization of relaxivity for MRI contrast agent applications at high magnetic field

Luminescent lanthanides bioprobes emitting in the visible and/or near-infrared ranges

Lanthanide Bimetallic Helicates for in Vitro Imaging and Sensing

Gadonanotubes as Ultrasensitive pH-Smart Probes for Magnetic Resonance Imaging

Effect of the length of polyoxyethylene substituents on luminescent bimetallic lanthanide bioprobes

In vivo MRI assessment of a novel GdIII-based contrast agent designed for high magnetic field applications

Phosphite-derivatized ruthenium-carbohydrate complexes in the catalytic hydration of nitriles

Gd(III)-EPTPAC16, a new self-assembling potential liver MRI contrast agent: in vitro characterization and in vivo animal imaging studies

Theoretical investigations of magnetic properties of MRI contrast agents and carbon nanostructures

Theoretical investigations of magnetic properties of MRI contrast agents and carbon nanostructures

A benzene-core trinuclear GdIII complex: towards the optimization of relaxivity for MRI contrast agent applications at high magnetic field

Effect of the length of polyoxyethylene substituents on luminescent bimetallic lanthanide bioprobes

Luminescent lanthanides bioprobes emitting in the visible and/or near-infrared ranges

In vivo MRI assessment of a novel GdIII-based contrast agent designed for high magnetic field applications

Gd(III)-EPTPAC16, a new self-assembling potential liver MRI contrast agent: in vitro characterization and in vivo animal imaging studies

Gadonanotubes as Ultrasensitive pH-Smart Probes for Magnetic Resonance Imaging

Towards the Rational Design of MRI Contrast Agents: Electron Spin Relaxation Is Largely Unaffected by the Coordination Geometry of Gadolinium(III)-DOTA-Type Complexes

Phosphite-derivatized ruthenium-carbohydrate complexes in the catalytic hydration of nitriles

Lanthanide Bimetallic Helicates for in Vitro Imaging and Sensing