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Timber Folded Plate Structures – Folded Form Analysis

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Structural Studies and Protein Engineering of Human O6-Alkylguanine-DNA Alkyltransferase

Birgit Mollwitz

The specific labeling of proteins with synthetic probes is a powerful approach to study protein function and protein tags have been widely used for this purpose. A well-established example for a self-labeling protein tag is SNAP-tag. It specifically reacts ...

EPFL2012

Buckling-induced encapsulation of structured elastic shells under pressure

Pedro Miguel Nunes Pereira de Almeida Reis

We introduce a class of continuum shell structures, the Buckliball, which undergoes a structural transformation induced by buckling under pressure loading. The geometry of the Buckliball comprises a spherical shell patterned with a regular array of circula ...

2012

Chemical Synthesis and Expression of the HIV-1 Rev Protein

Hilal Lashuel

The HIV-1 Rev protein is responsible for shuttling partially spliced and unspliced viral mRNA out of the nucleus. This is a crucial step in the HIV-1 lifecycle, thus making Rev an attractive target for the design of anti-HIV drugs. Despite its importance, ...

2011

Geometrical description and structural analysis of a modular timber structure

Yves Weinand, Seyed Sina Nabaei, Olivier Baverel

The ambitious goal of the ongoing research at IBOIS, the Laboratory of timber constructions at the Ecole Polytechnique Fédérale de Lausanne (EPFL) is to develop a next generation of timber constructions made out of innovative timber-derived products, throu ...

2011

A nonradial coarse-grained potential for proteins produces naturally stable secondary structure elements

Matteo Dal Peraro, Michele Cascella, Davide Alemani, Francesca Collu

We introduce a nonradial potential term for coarse-grained (CG) molecular simulations of proteins. This term mimics the backbone dipole−dipole interactions and accounts for the needed directionality to form stable folded secondary structure elements. We sh ...

2010

This research investigates new methods of designing folded plate structures that can be built with cross-laminated timber panels. Folded plate structures are attractive to both architects and engineers for their structural, spatial, and plastic qualities. ...

EPFL2010

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Thin-shell and rod theory using discrete mechanics applied to structures in civil engineering. The aim is to apply structure preserving algorithms to concrete problems in construction. The major objectives of this interdisciplinary work is the search and t ...

2009

Structural implications of ultra-high performance fibre-reinforced concrete in bridge design

Ana Spasojevic

The present research represents a theoretical and experimental contribution to the understanding of the structural behaviour of elements made of ultra-high performance fibre-reinforced concrete (UHPFRC). UHPFRC is investigated as an advanced cementitious m ...

EPFL2008

In conjunction with Hans-Ulrich Buri’s research, this thesis project addresses the engineering part of the folded Origami structures. The material employed for this type of structure is not necessarily defined. Therefore metal, concrete and timber realisat ...

2008

Background: Structural genomics initiatives are producing increasing numbers of three-dimensional (3D) structures for which there is little functional information. Structure-based annotation of molecular function is therefore becoming critical. We previous ...

BioMed Central2007