Genome projectGenome projects are scientific endeavours that ultimately aim to determine the complete genome sequence of an organism (be it an animal, a plant, a fungus, a bacterium, an archaean, a protist or a virus) and to annotate protein-coding genes and other important genome-encoded features. The genome sequence of an organism includes the collective DNA sequences of each chromosome in the organism. For a bacterium containing a single chromosome, a genome project will aim to map the sequence of that chromosome.
Whole genome sequencingWhole genome sequencing (WGS), also known as full genome sequencing, complete genome sequencing, or entire genome sequencing, is the process of determining the entirety, or nearly the entirety, of the DNA sequence of an organism's genome at a single time. This entails sequencing all of an organism's chromosomal DNA as well as DNA contained in the mitochondria and, for plants, in the chloroplast. Whole genome sequencing has largely been used as a research tool, but was being introduced to clinics in 2014.
Normal subgroupIn abstract algebra, a normal subgroup (also known as an invariant subgroup or self-conjugate subgroup) is a subgroup that is invariant under conjugation by members of the group of which it is a part. In other words, a subgroup of the group is normal in if and only if for all and The usual notation for this relation is Normal subgroups are important because they (and only they) can be used to construct quotient groups of the given group.
GenomeIn the fields of molecular biology and genetics, a genome is all the genetic information of an organism. It consists of nucleotide sequences of DNA (or RNA in RNA viruses). The nuclear genome includes protein-coding genes and non-coding genes, other functional regions of the genome such as regulatory sequences (see non-coding DNA), and often a substantial fraction of junk DNA with no evident function. Almost all eukaryotes have mitochondria and a small mitochondrial genome.
Commutator subgroupIn mathematics, more specifically in abstract algebra, the commutator subgroup or derived subgroup of a group is the subgroup generated by all the commutators of the group. The commutator subgroup is important because it is the smallest normal subgroup such that the quotient group of the original group by this subgroup is abelian. In other words, is abelian if and only if contains the commutator subgroup of . So in some sense it provides a measure of how far the group is from being abelian; the larger the commutator subgroup is, the "less abelian" the group is.
Human Genome ProjectThe Human Genome Project (HGP) was an international scientific research project with the goal of determining the base pairs that make up human DNA, and of identifying, mapping and sequencing all of the genes of the human genome from both a physical and a functional standpoint. It started in 1990 and was completed in 2003. It remains the world's largest collaborative biological project. Planning for the project started after it was adopted in 1984 by the US government, and it officially launched in 1990.
Bacterial genomeBacterial genomes are generally smaller and less variant in size among species when compared with genomes of eukaryotes. Bacterial genomes can range in size anywhere from about 130 kbp to over 14 Mbp. A study that included, but was not limited to, 478 bacterial genomes, concluded that as genome size increases, the number of genes increases at a disproportionately slower rate in eukaryotes than in non-eukaryotes. Thus, the proportion of non-coding DNA goes up with genome size more quickly in non-bacteria than in bacteria.
Focal subgroup theoremIn abstract algebra, the focal subgroup theorem describes the fusion of elements in a Sylow subgroup of a finite group. The focal subgroup theorem was introduced in and is the "first major application of the transfer" according to . The focal subgroup theorem relates the ideas of transfer and fusion such as described in . Various applications of these ideas include local criteria for p-nilpotence and various non-simplicity criteria focussing on showing that a finite group has a normal subgroup of index p.
SubgroupIn group theory, a branch of mathematics, given a group G under a binary operation ∗, a subset H of G is called a subgroup of G if H also forms a group under the operation ∗. More precisely, H is a subgroup of G if the restriction of ∗ to H × H is a group operation on H. This is often denoted H ≤ G, read as "H is a subgroup of G". The trivial subgroup of any group is the subgroup {e} consisting of just the identity element. A proper subgroup of a group G is a subgroup H which is a proper subset of G (that is, H ≠ G).
PhylogeneticsIn biology, phylogenetics (ˌfaɪloʊdʒəˈnɛtɪks,_-lə-) is the study of the evolutionary history and relationships among or within groups of organisms. These relationships are determined by phylogenetic inference methods that focus on observed heritable traits, such as DNA sequences, protein amino acid sequences, or morphology. The result of such an analysis is a phylogenetic tree—a diagram containing a hypothesis of relationships that reflects the evolutionary history of a group of organisms.
