Are you an EPFL student looking for a semester project?
Work with us on data science and visualisation projects, and deploy your project as an app on top of Graph Search.
PurposeTo determine a relationship between the retinal vessel saturation alterations and the residual retinal function measured by means of full-field electroretinography (full-field ERG), electrooculogram (EOG) and multifocal electroretinography (mfERG) in patients with retinitis pigmentosa (RP). MethodsRetinal vessel oximetry (RO), full-field ERG, EOG and mfERG were performed on 43 eyes of 22 patients suffering from RP and were compared to those of 26 eyes of 13 healthy controls. The oxygen saturation in the first and second branch retinal arterioles (A-SO2) and venules (V-SO2) was measured, and their difference (A-V SO2) was calculated. Full-field ERG amplitudes, EOG parameters and averaged mfERG response amplitudes (within central 3 degrees, between 3 degrees and 8 degrees, 8 degrees and 15 degrees, 15 degrees and 24 degrees) were evaluated in relation to the RO measurements. ResultsV-SO2 correlated negatively with the full-field ERG and EOG values, with increasing functional damage the V-SO2 was higher. The RP group was well distinguished from the controls when the RO measurements were correlated to the averaged N1 (baseline to trough), but also to the N1P1 (trough-to-peak) mfERG response amplitudes. Receiver operating characteristic (ROC) curve of V-SO2, compared to those of N1 and N1P1 mfERG response averages (15-24 degrees), presented a high differential margin between RP and controls (p
Francisco Javier Rincon Vallejos, Srinivasan Murali, Julien Pidoux
Diego Ghezzi, Marta Jole Ildelfonsa Airaghi Leccardi, Paola Vagni, Elodie Geneviève Zollinger, Charles-Henri Puncho Jérôme Vila, Golnaz Sherafatipour
Christophe Moser, Timothé Laforest, Laura Emmanuelle Kowalczuk, Mathieu Künzi