Publications related to Aberrant Accumulation of the Diabetes Autoantigen GAD65 in Golgi Membranes in Conditions of ER Stress and Autoimmunity

Dendritic cell chemotaxis in 3D

Dendritic cells (DCs) are crucial for the onset of adaptive immunity. Their outstanding migratory capacities in combination with their antigen presenting properties make them perfectly suited to pick up antigens in the periphery and transport them to the l ...

EPFL2010

Antigen delivery to dendritic cells by poly(propylene sulfide) nanoparticles with disulfide conjugated peptides: Cross-presentation and T cell activation

Jeffrey Alan Hubbell, Melody Swartz, Sachiko Hirosue, Iraklis Kourtis

Vaccines aiming to activate cytotoxic T cells require cross-presentation of exogenous antigen by antigen-presenting cells (APCs). We recently developed a synthetic nanoparticle vaccine platform that targets lymph node-resident dendritic cells (DCs), capabl ...

Elsevier2010

Towards high resolution optical imaging of beta cells in vivo

Theo Lasser, Anne Grapin-Botton, Martin Villiger, Joan Goulley, Erica Martin-Williams

Endocrine beta cells produce and release insulin in order to tightly regulate glucose homeostasis and prevent metabolic pathologies such as Diabetes Mellitus. Optical imaging has contributed greatly to our current understanding of beta cell structure and f ...

Bentham Science Publishers2010

Beta amyloid and hyperphosphorylated tau deposits in the pancreas in type 2 diabetes

László Forró, Aleksandra Radenovic, Andras Kis

Strong epidemiologic evidence suggests an association between Alzheimer disease (AD) and type 2 diabetes. To determine if amyloid beta (A

\beta

) and hyperphosphorylated tau occurs in type 2 diabetes, pancreas tissues from 21 autopsy cases (10 type 2 diabe ...

Elsevier2010

Homing of GAD65 specific autoimmunity and development of insulitis requires expression of both DQ8 and human GAD65 in transgenic mice

Steinunn Baekkeskov Hanahan

MHC-class II genes determine susceptibility in human type-1 diabetes. In their context, presentation of target antigen(s) results in autoimmunity and b-cell destruction. An animal model, in which human b-cell autoantigen(s) are presented to effector cells ...

Elsevier2009

Exploiting immunofunctional nanoparticles as vaccines and synthetic pathogens

Sai Reddy

The emergence of recombinant DNA technology has shifted research towards developing subunit vaccines, which use protein or peptide antigens instead of live/attenuated pathogens. Recent research has also shown that the best way to get sustained immunity is ...

EPFL2008

Palmitoylation and ubiquitination regulate exit of the Wnt signaling protein LRP6 from the endoplasmic reticulum

Françoise Gisou van der Goot Grunberg, Laurence Gouzi Abrami, Béatrice Kunz, Mircea Ioan Iacovache

Canonical Wnt signaling is initiated by binding of Wnt proteins to members of the Frizzled family and subsequent complex formation with lipoprotein receptor-related proteins 5/6 (LRP5/6). Here, we show that LRP6 is palmitoylated on a juxtamembranous cystei ...

2008

Notch signaling is required for exocrine regeneration after acute pancreatitis

Freddy Radtke

BACKGROUND & AIMS: The mechanisms for tissue regeneration and renewal after acute pancreatitis are not well understood but may involve activation of Notch signaling. To study the effect of Notch signaling ablation during acute experimental pancreatitis, we ...

2008

Involvement of a Golgi-resident GPI-anchored protein in maintenance of the Golgi structure

Françoise Gisou van der Goot Grunberg, Xuan Li

The Golgi apparatus consists of a series of flattened cisternal membranes that are aligned in parallel to form stacks. Cytosolic-oriented Golgi-associated proteins have been identified that may coordinate or maintain the Golgi architecture. Here, we descri ...

2007

Expression of lymphotoxin beta governs immunity at two distinct levels

Nicola Harris

Interaction of lymphotoxin alpha(1)beta(2) (LTalpha(1)beta(2)) with its receptor is key for the generation and maintenance of secondary lymphoid organ microstructure. We used mice conditionally deficient for LTbeta on different lymphocyte subsets to determ ...

2006

Aberrant Accumulation of the Diabetes Autoantigen GAD65 in Golgi Membranes in Conditions of ER Stress and Autoimmunity

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Dendritic cell chemotaxis in 3D

Antigen delivery to dendritic cells by poly(propylene sulfide) nanoparticles with disulfide conjugated peptides: Cross-presentation and T cell activation

Towards high resolution optical imaging of beta cells in vivo

Beta amyloid and hyperphosphorylated tau deposits in the pancreas in type 2 diabetes

Homing of GAD65 specific autoimmunity and development of insulitis requires expression of both DQ8 and human GAD65 in transgenic mice

Exploiting immunofunctional nanoparticles as vaccines and synthetic pathogens

Palmitoylation and ubiquitination regulate exit of the Wnt signaling protein LRP6 from the endoplasmic reticulum

Notch signaling is required for exocrine regeneration after acute pancreatitis

Involvement of a Golgi-resident GPI-anchored protein in maintenance of the Golgi structure

Expression of lymphotoxin beta governs immunity at two distinct levels

Antigen delivery to dendritic cells by poly(propylene sulfide) nanoparticles with disulfide conjugated peptides: Cross-presentation and T cell activation

Dendritic cell chemotaxis in 3D

Towards high resolution optical imaging of beta cells in vivo

Expression of lymphotoxin beta governs immunity at two distinct levels

Beta amyloid and hyperphosphorylated tau deposits in the pancreas in type 2 diabetes

Homing of GAD65 specific autoimmunity and development of insulitis requires expression of both DQ8 and human GAD65 in transgenic mice

Involvement of a Golgi-resident GPI-anchored protein in maintenance of the Golgi structure

Palmitoylation and ubiquitination regulate exit of the Wnt signaling protein LRP6 from the endoplasmic reticulum

Exploiting immunofunctional nanoparticles as vaccines and synthetic pathogens

Notch signaling is required for exocrine regeneration after acute pancreatitis