Evaluating Gene Expression Dynamics Using Pairwise RNA FISH Data
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Tumor plasticity and the heterogeneous response of melanoma cells to targeted therapies are major limits for the long-term efficacy of this line of therapy. Targeting tumor plasticity is theoretically possible through the modulation of the expression of RN ...
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The advent of experimental techniques for the time-course monitoring of gene expression at the single-cell level has paved the way to the model-based study of gene expression variability within- an across-cells. A number of approaches to the inference of m ...
The evolution of tetrapod limbs from fish fins enabled the conquest of land by vertebrates and thus represents a key step in evolution. Despite the use of comparative gene expression analyses, critical aspects of this transformation remain controversial, i ...
A robotic fish accepted by animals as conspecifics is a very powerful tool in behavioral biology. To obtain the acceptance of the device towards the animals, it should generate some visual stimuli that can be perceived by a living fish as attractive signal ...
The patch-clamp technique has allowed for detailed studies on the electrical properties of neurons. Dye loading through patch pipettes enabled characterizing the morphological properties of the neurons. In addition, the patch-clamp technique also allows fo ...
Effect concentrations in the toxicity assessment of chemicals with fish and fish cells are generally based on external exposure concentrations. External concentrations as dose metrics, may, however, hamper interpretation and extrapolation of toxicological ...
The advent of experimental techniques for the time-course monitoring of gene expression at the single-cell level has paved the way to the model-based study of gene expression variability within- an across-cells. A number of approaches to the inference of m ...
Tetracyclines, a class of antibiotics that target bacterial translation, are commonly used in research for inducible gene expression using Tet-ON/Tet-OFF systems. However, such tetracycline-inducible systems carry a risk. Given that mitochondria have a "ba ...