Population structure (genetics)Population structure (also called genetic structure and population stratification) is the presence of a systematic difference in allele frequencies between subpopulations. In a randomly mating (or panmictic) population, allele frequencies are expected to be roughly similar between groups. However, mating tends to be non-random to some degree, causing structure to arise. For example, a barrier like a river can separate two groups of the same species and make it difficult for potential mates to cross; if a mutation occurs, over many generations it can spread and become common in one subpopulation while being completely absent in the other.
Population geneticsPopulation genetics is a subfield of genetics that deals with genetic differences within and among populations, and is a part of evolutionary biology. Studies in this branch of biology examine such phenomena as adaptation, speciation, and population structure. Population genetics was a vital ingredient in the emergence of the modern evolutionary synthesis. Its primary founders were Sewall Wright, J. B. S. Haldane and Ronald Fisher, who also laid the foundations for the related discipline of quantitative genetics.
Demographic transitionIn demography, demographic transition is a phenomenon and theory which refers to the historical shift from high birth rates and high death rates in societies with minimal technology, education (especially of women) and economic development, to low birth rates and low death rates in societies with advanced technology, education and economic development, as well as the stages between these two scenarios.
MacOSmacOS (ˌmækoʊˈɛs; previously OS X and originally Mac OS X) is an operating system developed and marketed by Apple Inc. since 2001. It is the primary operating system for Apple's Mac computers. Within the market of desktop and laptop computers, it is the second most widely used desktop OS, after Microsoft Windows and ahead of Linux (including ChromeOS). macOS succeeded the classic Mac OS, a Mac operating system with nine releases from 1984 to 1999.
Mac OS 8Mac OS 8 is an operating system that was released by Apple Computer on July 26, 1997. It includes the largest overhaul of the classic Mac OS experience since the release of System 7, approximately six years before. It places a greater emphasis on color than prior versions. Released over a series of updates, Mac OS 8 represents an incremental integration of many of the technologies which had been developed from 1988 to 1996 for Apple's overly ambitious OS named Copland.
Mac OS 9Mac OS 9 is the ninth and final major release of Apple's classic Mac OS operating system which was succeeded by Mac OS X (renamed to OS X in 2011 and macOS in 2016) in 2001. Introduced on October 23, 1999, it was promoted by Apple as "The Best Internet Operating System Ever", highlighting Sherlock 2's Internet search capabilities, integration with Apple's free online services known as iTools and improved Open Transport networking.
Gene–environment correlationGene–environment correlation (or genotype–environment correlation) is said to occur when exposure to environmental conditions depends on an individual's genotype. Gene–environment correlations (or rGE) is correlation of two traits, e.g. height and weight, which would mean that when one changes, so does the other. Gene–environment correlations can arise by both causal and non-causal mechanisms. Of principal interest are those causal mechanisms which indicate genetic control over environmental exposure.
Genome-wide association studyIn genomics, a genome-wide association study (GWA study, or GWAS), is an observational study of a genome-wide set of genetic variants in different individuals to see if any variant is associated with a trait. GWA studies typically focus on associations between single-nucleotide polymorphisms (SNPs) and traits like major human diseases, but can equally be applied to any other genetic variants and any other organisms. When applied to human data, GWA studies compare the DNA of participants having varying phenotypes for a particular trait or disease.
Effective population sizeThe effective population size (Ne) is a number that, in some simplified scenarios, corresponds to the number of breeding individuals in the population. More generally, Ne is the number of individuals that an idealised population would need to have in order for some specified quantity of interest (typically change of genetic diversity or inbreeding rates) to be the same as in the real population. Idealised populations are based on unrealistic but convenient simplifications such as random mating, simultaneous birth of each new generation, constant population size, and equal numbers of children per parent.
Candidate geneThe candidate gene approach to conducting genetic association studies focuses on associations between genetic variation within pre-specified genes of interest, and phenotypes or disease states. This is in contrast to genome-wide association studies (GWAS), which is a hypothesis-free approach that scans the entire genome for associations between common genetic variants (typically SNPs) and traits of interest. Candidate genes are most often selected for study based on a priori knowledge of the gene's biological functional impact on the trait or disease in question.
