HaploinsufficiencyHaploinsufficiency in genetics describes a model of dominant gene action in diploid organisms, in which a single copy of the wild-type allele at a locus in heterozygous combination with a variant allele is insufficient to produce the wild-type phenotype. Haploinsufficiency may arise from a de novo or inherited loss-of-function mutation in the variant allele, such that it yields little or no gene product (often a protein). Although the other, standard allele still produces the standard amount of product, the total product is insufficient to produce the standard phenotype.
History of the Jews in TunisiaThe history of the Jews in Tunisia extended nearly two thousand years and goes back to the Punic era. The Jewish community in Tunisia is no doubt older and grew up following successive waves of immigration and proselytism before its development was hampered by anti-Jewish measures in the Byzantine Empire. The community formerly used its own dialect of Arabic. After the Muslim conquest of Tunisia, Tunisian Judaism went through periods of relative freedom or even cultural apogee to times of more marked discrimination.
Constitution of TunisiaThe Constitution of Tunisia is the supreme law of the Tunisian Republic. The constitution is the framework for the organization of the Tunisian government and for the relationship of the federal government with the governorates, citizens, and all people within Tunisia. Tunisia's first modern constitution was the Fundamental Pact of 1857. This was followed by the Constitution of 1861, which was not replaced until after the departure of French administrators in 1956, by the constitution of 1959.
PenetrancePenetrance in genetics is the proportion of individuals carrying a particular variant (or allele) of a gene (the genotype) that also expresses an associated trait (the phenotype). In medical genetics, the penetrance of a disease-causing mutation is the proportion of individuals with the mutation that exhibit clinical symptoms among all individuals with such mutation. For example, if a mutation in the gene responsible for a particular autosomal dominant disorder has 95% penetrance, then 95% of those with the mutation will develop the disease, while 5% will not.
Variant of uncertain significanceA variant of uncertain (or unknown) significance (VUS) is a genetic variant that has been identified through genetic testing but whose significance to the function or health of an organism is not known. Two related terms are "gene of uncertain significance" (GUS), which refers to a gene that has been identified through genome sequencing but whose connection to a human disease has not been established, and "insignificant mutation", referring to a gene variant that has no impact on the health or function of an organism.
