Observational studyIn fields such as epidemiology, social sciences, psychology and statistics, an observational study draws inferences from a sample to a population where the independent variable is not under the control of the researcher because of ethical concerns or logistical constraints. One common observational study is about the possible effect of a treatment on subjects, where the assignment of subjects into a treated group versus a control group is outside the control of the investigator.
Clinical study designClinical study design is the formulation of trials and experiments, as well as observational studies in medical, clinical and other types of research (e.g., epidemiological) involving human beings. The goal of a clinical study is to assess the safety, efficacy, and / or the mechanism of action of an investigational medicinal product (IMP) or procedure, or new drug or device that is in development, but potentially not yet approved by a health authority (e.g. Food and Drug Administration).
Bayesian probabilityBayesian probability (ˈbeɪziən or ˈbeɪʒən ) is an interpretation of the concept of probability, in which, instead of frequency or propensity of some phenomenon, probability is interpreted as reasonable expectation representing a state of knowledge or as quantification of a personal belief. The Bayesian interpretation of probability can be seen as an extension of propositional logic that enables reasoning with hypotheses; that is, with propositions whose truth or falsity is unknown.
Regularized least squaresRegularized least squares (RLS) is a family of methods for solving the least-squares problem while using regularization to further constrain the resulting solution. RLS is used for two main reasons. The first comes up when the number of variables in the linear system exceeds the number of observations. In such settings, the ordinary least-squares problem is ill-posed and is therefore impossible to fit because the associated optimization problem has infinitely many solutions.
Partial least squares regressionPartial least squares regression (PLS regression) is a statistical method that bears some relation to principal components regression; instead of finding hyperplanes of maximum variance between the response and independent variables, it finds a linear regression model by projecting the predicted variables and the observable variables to a new space. Because both the X and Y data are projected to new spaces, the PLS family of methods are known as bilinear factor models.
EvidenceEvidence for a proposition is what supports the proposition. It is usually understood as an indication that the supported proposition is true. What role evidence plays and how it is conceived varies from field to field. In epistemology, evidence is what justifies beliefs or what makes it rational to hold a certain doxastic attitude. For example, a perceptual experience of a tree may act as evidence that justifies the belief that there is a tree. In this role, evidence is usually understood as a private mental state.
Nuclear weapon yieldThe explosive yield of a nuclear weapon is the amount of energy released such as blast, thermal, and nuclear radiation, when that particular nuclear weapon is detonated, usually expressed as a TNT equivalent (the standardized equivalent mass of trinitrotoluene which, if detonated, would produce the same energy discharge), either in kilotonnes (kt—thousands of tonnes of TNT), in megatonnes (Mt—millions of tonnes of TNT), or sometimes in terajoules (TJ). An explosive yield of one terajoule is equal to .
LinearityIn mathematics, the term linear is used in two distinct senses for two different properties: linearity of a function (or mapping ); linearity of a polynomial. An example of a linear function is the function defined by that maps the real line to a line in the Euclidean plane R2 that passes through the origin. An example of a linear polynomial in the variables and is Linearity of a mapping is closely related to proportionality. Examples in physics include the linear relationship of voltage and current in an electrical conductor (Ohm's law), and the relationship of mass and weight.
Disability-adjusted life yearThe disability-adjusted life year (DALY) is a measure of overall disease burden, expressed as the number of years lost due to ill-health, disability or early death. It was developed in the 1990s as a way of comparing the overall health and life expectancy of different countries. The DALY has become more common in the field of public health and health impact assessment (HIA). It not only includes the potential years of life lost due to premature death, but also includes equivalent years of 'healthy' life lost by virtue of being in states of poor health or disability.
Nuclear weapons testingNuclear weapons tests are experiments carried out to determine the performance, yield, and effects of nuclear weapons. Testing nuclear weapons offers practical information about how the weapons function, how detonations are affected by different conditions, and how personnel, structures, and equipment are affected when subjected to nuclear explosions. However, nuclear testing has often been used as an indicator of scientific and military strength.
