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Embryonic timing, axial stem cells, chromatin dynamics, and the Hox clock

Related publications (55)

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Tetrapod axial evolution and developmental constraints; Empirical underpinning by a mouse model

Denis Duboule

The tetrapod vertebral column has become increasingly complex during evolution as an adaptation to a terrestrial life. At the same time, the evolution of the vertebral formula became subject to developmental constraints acting on the size of the cervical a ...

Elsevier2015

A switch between topological domains underlies HoxD genes collinearity in mouse limbs

Didier Trono, Denis Duboule, Marion Leleu, Daniël Noordermeer, Guillaume Andrey

Hox genes are major determinants of the animal body plan, where they organize structures along both the trunk and appendicular axes. During mouse limb development, Hoxd genes are transcribed in two waves: early on, when the arm and forearm are specified, a ...

Amer Assoc Advancement Science2013

SPBC: Leveraging the Characteristics of MPI HPC Applications for Scalable Checkpointing

André Schiper, Thomas Ropars

The high failure rate expected for future supercomputers requires the design of new fault tolerant solutions. Most checkpointing protocols are designed to work with any message-passing application but suffer from scalability issues at extreme scale. We tak ...

2013

Chromatin architectures and hox gene collinearity

Denis Duboule, Daniël Noordermeer

Ever since the observation that collinearity, that is, the sequential activity of Hox genes based on their relative positions within their gene clusters, is conserved throughout most of the animal kingdom, the question has been raised as to what are the un ...

Elsevier Academic Press Inc2013

Role of a polymorphism in a Hox/Pax-responsive enhancer in the evolution of the vertebrate spine

Denis Duboule

Patterning of the vertebrate skeleton requires the coordinated activity of Hox genes. In particular, Hox10 proteins are essential to set the transition from thoracic to lumbar vertebrae because of their rib-repressing activity. In snakes, however, the thor ...

Natl Acad Sciences2013

N° 2 Lighthouse Project 2e éd.

Dieter Dietz, Aline Dubach

The Lighthouse Project proposes a house. Named a House it had to address inhabitation: for whom was defined by each student. Additionally the Lighthouse had to include a public function. Light was considered as an attractor and conductor of flows in the ur ...

2011

Relation between near–field and far–field properties of plasmonic Fano resonances

Olivier Martin, Benjamin Gallinet

The relation between the near–field and far–field properties of plasmonic nanostructures that exhibit Fano resonances is investigated in detail. We show that specific features visible in the asymmetric lineshape far–field response of such structures origin ...

Optical Society of America2011

Structural and functional differences in the long non-coding RNA hotair in mouse and human

Denis Duboule, Patrick Schorderet

Long non-coding RNAs regulate various biological processes such as dosage compensation, imprinting, and chromatin organization. HOTAIR, a paradigm of this new class of RNAs, is localized within the human HOXC gene cluster and was shown, in human cells, to ...

Public Library of Science2011

Escola a Manresa / School in Manresa

Sergi Aguacil Moreno

The project is developed around a central courtyard in response to the site where it is located, while taking advantage of the existing slope to resolve the position of the singular buildings in relation to the system of grouping classrooms; the direct con ...

2010

Squatting the Sea

Harry Gugger

Chapter in the exhibition catalogue outlining the instigation and concept for the creation of the exhibition at the Biennale. The text focuses on the relation of urban development in Bahrain with the traditional and cultural connection to water and the sea ...

Kingdom of Bahrain2010