Aerobic exercise and a BDNF-mimetic therapy rescue learning and memory in a mouse model of Down syndrome
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Since its introduction 16 years ago, the astrocyte-neuron lactate shuttle (ANLS) model has profoundly modified our understanding of neuroenergetics by bringing a cellular and molecular resolution. Praised or disputed, the concept has never ceased to attrac ...
Exercise The architectonic space is an exercise in architecture. It invites students to follow a particular approach to design that, for pedagogical purposes, limits the number of questions considered, in order to privilege a specific dimension of architec ...
Down syndrome (DS) is the most frequent cause of cognitive disability in children and adults. It has been reported that defects in neurogenesis occur both during development and adulthood and possibly underlie cognitive dysfunction associated with DS. Rece ...
In this paper, we explore the possibility of a general framework for modelling engagement dynamics in software tutoring, focusing on the cases of developmental dyslexia and developmental dyscalculia. This project aims at capturing the similar engagement st ...
Down syndrome (DS) is the most frequent cause of mental retardation in adults and children. It has been proposed that cognitive disabilities associated with DS may be ascribed to neurogenesis impairment during both development and adulthood. This view is s ...
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This paper describes the European Commission (EC) Framework 7 funded project myCopter (2011-2014). The project is still at an early stage so the paper starts with a discussion of the current transportation issues faced, for example, by European countries a ...
BACKGROUND: Brain-derived neurotrophic factor (BDNF) is believed to be an important regulator of striatal neuron survival, differentiation, and plasticity. Moreover, reduction of BDNF delivery to the striatum has been implicated in the pathophysiology of H ...
